IMMUNOCYTOCHEMICAL LOCALIZATION OF TRANSFORMING GROWTH-FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN FALLOPIAN-TUBES AND CUMULUS CELLS

被引：17

作者：

ELDANASOURI, I ^{[1
]}

FRANCES, A ^{[1
]}

WESTPHAL, LM ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT GYNECOL & OBSTET,STANFORD,CA 94305

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1993年 / 30卷 / 2-3期

关键词：

GROWTH FACTORS; EMBRYONIC DEVELOPMENT; AUTOCRINE;

D O I：

10.1111/j.1600-0897.1993.tb00606.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PROBLEM: Transforming growth factor-alpha (TGF-alpha) has been shown to be a potent stimulant of oocyte maturation and embryonic development. The role of maternal growth factors and their mechanism of action in early mammalian development is not well understood. METHOD: In this study, the presence of TGF-alpha and epidermal growth factor receptor (EGF-R) in human cumulus cells and fallopian tubes was investigated by immunocytochemical techniques. RESULTS: The fallopian tube showed intense staining for TGF-alpha in the apical region of the epithelial cells, and the cumulus cells showed intense staining for EGF-R on cell membranes. CONCLUSION: The presence of TGF-alpha in the fallopian tube epithelium and its receptor on cumulus cells suggest a paracrine mechanism between maternal growth factors and the developing embryo.

引用

页码：82 / 87

页数：6

共 50 条

[21] OVEREXPRESSION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN PANCREATIC-CANCER IS ASSOCIATED WITH CONCOMITANT INCREASES IN THE LEVELS OF EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA
KORC, M
CHANDRASEKAR, B
YAMANAKA, Y
FRIESS, H
BUCHLER, M
BEGER, HG
JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (04): : 1352 - 1360
[22] PROLIFERATION OF HUMAN COLON CANCER-CELLS - ROLE OF EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA
HUANG, S
TRUJILLO, JM
CHAKRABARTY, S
INTERNATIONAL JOURNAL OF CANCER, 1992, 52 (06) : 978 - 986
[23] Immunocytochemical localization of transforming growth factor alpha, epidermal growth factor and epidermal growth factor receptor in the cat endometrium and placenta
Boomsma, RA
Mavrogianis, PA
Verhage, HG
HISTOCHEMICAL JOURNAL, 1997, 29 (06): : 495 - 504
[24] LOCALIZATION OF TRANSFORMING GROWTH FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN BURN WOUNDS
WENCZAK, B
KING, LE
NANNEY, LB
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 98 (04) : 614 - 614
[25] LOCALIZATION OF TRANSFORMING GROWTH FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN BURN WOUNDS
WENCZAK, B
KING, LE
NANNEY, LB
CLINICAL RESEARCH, 1992, 40 (02): : A476 - A476
[26] IDENTIFICATION OF EPIDERMAL GROWTH-FACTOR, TRANSFORMING GROWTH-FACTOR-ALPHA, AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN SURGICALLY INDUCED PELVIC ADHESIONS IN THE RAT AND INTRAPERITONEAL ADHESIONS IN THE HUMAN
CHEGINI, N
SIMMS, J
WILLIAMS, RS
MASTERSON, BJ
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1994, 171 (02) : 321 - 328
[27] IMMUNOCYTOCHEMICAL (ICC) LOCALIZATION OF TRANSFORMING GROWTH-FACTOR-ALPHA (TGF-ALPHA), EPIDERMAL GROWTH-FACTOR (EGF) AND EGF-RECEPTOR (EGFR) IN THE CAT ENDOMETRIUM AND PLACENTA
BOOMSMA, RA
MAVROGIANIS, PA
VERHAGE, HG
BIOLOGY OF REPRODUCTION, 1995, 52 : 88 - 88
[28] THE EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA IN RENAL-CELL CARCINOMA
LAGER, DJ
SLAGEL, DD
PALECHEK, PL
MODERN PATHOLOGY, 1994, 7 (05) : 544 - 548
[29] RELATIONSHIP BETWEEN TRANSFORMING GROWTH-FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN IDIOPATHIC PULMONARY FIBROSIS
BAUGHMAN, RP
MILLER, MA
HEFFELFINGER, S
LOWER, EE
CLINICAL RESEARCH, 1994, 42 (03): : A426 - A426
[30] TRANSFORMING GROWTH-FACTOR-ALPHA STIMULATES EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR-RELATED PROTEIN
POGREBNOY, PV
GARMANCHUK, LV
LUKYANOV, AV
TARNAVSKY, DV
BYKOREZ, AI
EKSPERIMENTALNAYA ONKOLOGIYA, 1993, 15 (05): : 30 - 32

← 1 2 3 4 5 →