SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES .30. SYNTHESIS AND ANTIVIRAL ACTIVITY OF 3'-AZIDO, 2',3'-UNSATURATED AND 2',3'-DIDEOXY DERIVATIVES OF E-5-STYRYL-2'-DEOXYURIDINE ON HUMAN-IMMUNODEFICIENCY-VIRUS

被引：6
|
作者：
YAMAGUCHI, T
SANEYOSHI, M
机构：
[1] Department of Biological Sciences, The Nishi-Tokyo University, Uenohara
来源：
NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 2-4期
关键词：
D O I：
10.1080/07328319208021711
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some new 3'-azido, 2',3'-unsaturated and 2',3'-dideoxy 5-styryl analogs of deoxyuridine-related compounds have been synthesized and evaluated against human immunodeficiency virus in vitro. Among these compounds, 3'-azido-2',3'-dideoxy-5-E-styryluridine (6) and 2',3'-dideoxy-E-5-styryluridine (9) were found to be active, with ED50 values of 5 and 10-mu-g/ml respectively.
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收藏
页码：373 / 382
页数：10
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