SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES .30. SYNTHESIS AND ANTIVIRAL ACTIVITY OF 3'-AZIDO, 2',3'-UNSATURATED AND 2',3'-DIDEOXY DERIVATIVES OF E-5-STYRYL-2'-DEOXYURIDINE ON HUMAN-IMMUNODEFICIENCY-VIRUS

被引：6
|
作者：
YAMAGUCHI, T
SANEYOSHI, M
机构：
[1] Department of Biological Sciences, The Nishi-Tokyo University, Uenohara
来源：
NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 2-4期
关键词：
D O I：
10.1080/07328319208021711
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some new 3'-azido, 2',3'-unsaturated and 2',3'-dideoxy 5-styryl analogs of deoxyuridine-related compounds have been synthesized and evaluated against human immunodeficiency virus in vitro. Among these compounds, 3'-azido-2',3'-dideoxy-5-E-styryluridine (6) and 2',3'-dideoxy-E-5-styryluridine (9) were found to be active, with ED50 values of 5 and 10-mu-g/ml respectively.
引用
收藏
页码：373 / 382
页数：10
相关论文
共 50 条
  • [21] SYNTHESES OF [2-C-14] 2,5'-ANHYDRO-3'-AZIDO-3'-DEOXYTHYMIDINE AND [2-C-14] 2,5'-ANHYDRO-3'-AZIDO-2',3'-DIDEOXY-5-IODOURIDINE - INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV-1)
    LIN, TS
    LIU, MC
    AUGUST, EM
    BIRKS, EM
    PRUSOFF, WH
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1991, 29 (12): : 1315 - 1321
  • [22] SYNTHESIS AND BIOLOGICAL EVALUATION OF 2',3'-DIDEOXY-L-PYRIMIDINE NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) AND HEPATITIS-B VIRUS (HBV)
    LIN, TS
    LUO, MZ
    LIU, MC
    PAI, SB
    DUTSCHMAN, GE
    CHENG, YC
    JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (06) : 798 - 803
  • [23] NUCLEOSIDES .54. SYNTHESIS AND PROPERTIES OF 3'-AZIDO AND 2',3'-DIDEOXY-6,7-DIPHENYLLUMAZINE NUCLEOSIDES
    CAO, XD
    PFLEIDERER, W
    NUCLEOSIDES & NUCLEOTIDES, 1994, 13 (1-3): : 773 - 798
  • [24] Synthesis and antiviral activity of L-3'-fluoro-2',3'-unsaturated carbocyclic nucleosides
    Wang, Jianing
    Jin, Yunho
    Schinazi, Raymond F.
    Chu, C. K.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [25] SYNTHESIS OF 3'-AZIDO-2',3'-DIDEOXY-BETA-D-ARABINO-HEXOPYRANOSYL NUCLEOSIDES
    HANSEN, P
    LAU, J
    PEDERSEN, EB
    NIELSEN, CM
    LIEBIGS ANNALEN DER CHEMIE, 1990, (11): : 1079 - 1082
  • [26] NEW STRATEGIES IN THE SYNTHESIS OF 3'-AZIDO-2',3'-DIDEOXY-NUCLEOSIDES WITH FURANOSE CONFIGURATION
    WENGEL, J
    LAU, J
    WALCZAK, K
    PEDERSEN, EB
    NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3): : 405 - 408
  • [27] INHIBITION OF REPRODUCTION OF HUMAN-IMMUNODEFICIENCY-VIRUS IN CELL-CULTURE BY 5'-PHOSPHONATES OF 3'-AZIDO-2',3'-DIDEOXYNUCLEOSIDES
    TARUSOVA, NB
    KHORLIN, AA
    KRAEVSKII, AA
    KORNEEVA, MN
    NOSIK, DN
    KRUGLOV, IV
    GALEGOV, GA
    BIBILASHVILI, RS
    MOLECULAR BIOLOGY, 1989, 23 (06) : 1361 - 1368
  • [28] Nucleotides -: Part LVI -: Synthesis and biological activity of modified (2′-5′)triadenylates containing 2′-terminal 2′,3′-dideoxy-3′-fluoroadenosine derivatives
    Kvasyuk, EI
    Kulak, TI
    Tkachenko, OV
    Sentyureva, SL
    Mikhailopulo, IA
    Suhadolnik, RJ
    Henderson, EE
    Horvath, SE
    Guan, MX
    Pfleiderer, W
    HELVETICA CHIMICA ACTA, 1998, 81 (07) : 1278 - 1284
  • [29] SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) BY 3'-AZIDO-2',3'-DIDEOXYGUANOSINE INVITRO
    BABA, M
    PAUWELS, R
    BALZARINI, J
    HERDEWIJN, P
    DECLERCQ, E
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 145 (03) : 1080 - 1086
  • [30] INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INTEGRASE BY 3'-AZIDO-2',3'-DIDEOXYTHYMIDYLATE
    MAZUMDER, A
    COONEY, D
    AGBARIA, R
    GUPTA, M
    POMMIER, Y
    FASEB JOURNAL, 1994, 8 (07): : A1468 - A1468
12345