NOVEL BRIDGEHEAD NITROGEN-HETEROCYCLES - SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 5H-PYRAZOLO[3', 4'/4, 5]THIAZOLO[3, 2-A]-PYRIMIDINES

被引：0

作者：

MOHAN, J

VERMA, P

机构：

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1993年 / 32卷 / 09期

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中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 2, 3-diaryl-6, 7-dihydro-5H-pyrazolo[3', 4': 4, 5]thiazolo[3, 2-a]pyrimidines (III) has been achieved in a single step by treating 2-arylidene-6, 7-dihydro-5H-thiazolo[3, 2-a]pyrimidin-3(2H)-ones (II) with hydrazines. Compounds II in turn have been obtained in a single step by condensing 3, 4, 5, 6-tetrahydropyrimidine-2-thione (I) with ethyl chloroacetate and aldehydes in the presence of pyridine and piperidine. Compounds III constitute a novel and hitherto unknown heterocyclic system. The antibacterial and antifungal activities of some of the compounds pertaining to this system have also been evaluated.

引用

页码：986 / 988

页数：3

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