NOVEL BRIDGEHEAD NITROGEN-HETEROCYCLES - SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 5H-PYRAZOLO[3', 4'/4, 5]THIAZOLO[3, 2-A]-PYRIMIDINES

被引：0

作者：

MOHAN, J

VERMA, P

机构：

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1993年 / 32卷 / 09期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 2, 3-diaryl-6, 7-dihydro-5H-pyrazolo[3', 4': 4, 5]thiazolo[3, 2-a]pyrimidines (III) has been achieved in a single step by treating 2-arylidene-6, 7-dihydro-5H-thiazolo[3, 2-a]pyrimidin-3(2H)-ones (II) with hydrazines. Compounds II in turn have been obtained in a single step by condensing 3, 4, 5, 6-tetrahydropyrimidine-2-thione (I) with ethyl chloroacetate and aldehydes in the presence of pyridine and piperidine. Compounds III constitute a novel and hitherto unknown heterocyclic system. The antibacterial and antifungal activities of some of the compounds pertaining to this system have also been evaluated.

引用

页码：986 / 988

页数：3

共 50 条

[21] Synthesis of 5H-pyrazolo[4,3-c]quinolines
Silin, OV
Savchenko, TI
Kovalenko, SM
Nikitchenko, VM
Ivachtchenko, AV
HETEROCYCLES, 2004, 63 (08) : 1883 - +
[22] Novel spiroheterocyclic systems containing bridgehead nitrogen atom:: Synthesis and antimicrobial activity of spirotetralin-1′,7 (8H)-[6H]-pyrazolo [3′,4′:4,5] thiazolo [3,2-b]-s-tetrazine
Mohan, J
Kumar, A
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 10 (02) : 89 - 92
[23] Bridgehead nitrogen heterocyclic systems:: Synthesis and antimicrobial activity of quinoxalino [2′,3′:4,5] thiazolo [2,3-b] pyrimidino [5,6-a] cyclooctene
Mohan, J
Goel, S
Anupama
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 14 (04) : 369 - 370
[24] NOVEL BRIDGEHEAD NITROGEN HETEROCYCLIC-SYSTEMS - FACILE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SPIRO[CYCLODODECANE-1,7'(8'H)-[6H]-PYRAZOLO[3',4'/4,5]THIAZOLO[3,2-B]-S-TETRAZINES]
MOHAN, J
SINGH, V
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1993, 32 (09): : 957 - 959
[25] Synthesis and antimicrobial activity of some new pyrazolo[3,4-d] pyrimidines and thiazolo[4,5-d]pyrimidines
Akbari, J. D.
Mehta, K. B.
Pathak, S. J.
Joshi, H. S.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2008, 47 (03): : 477 - 480
[26] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF BRIDGEHEAD NITROGEN-HETEROCYCLES - REACTIONS OF 3-N-METHYL/ETHYL/(ALPHA-METHYL)ETHYLMORPHOLINO/PIPERIDINO-4-AMINO-5-MERCAPTO-4(H)-1,2,4-TRIAZOLES
HOSUR, MC
TALAWAR, MB
LADDI, UV
BENNUR, RS
BENNUR, SC
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1995, 34 (08): : 707 - 712
[27] Condensed bridgehead nitrogen heterocyclic systems:: Synthesis, bioactivity and stereochemistry of pyrazolo [3′,4′:4,5] thiazolo [3,2-b]-s-triazoles
Mohan, J
Kumar, A
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 13 (02) : 97 - 100
[28] Condensed bridgehead nitrogen heterocyclic systems:: Synthesis, stereochemistry and bioactivity of pyrazolo [3′,4′:4,5] thiazolo [3,2-b]-s-triazoles
Kumar, Parvin
Mohan, Jag
Makrandi, J. K.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 16 (02) : 203 - 204
[29] Condensed bridgehead nitrogen heterocyclic systems:: Synthesis, bioactivity and stereochemistry of pyrazolo [3′,4′:4,5][thiazolo [3,2-b]-s-triazoles
Mohan, J
Kumar, A
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2002, 11 (04) : 261 - 264
[30] Condensed bridgehead nitrogen heterocyclic systems:: synthesis, bioactivity and stereochemistry of pyrazolo [3′,4′:4,5] thiazolo [3,2-b]-s-triazoles
Mohan, J
Kumar, A
Kumar, P
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 12 (04) : 375 - 376

← 1 2 3 4 5 →