SYNTHESES OF 5'-SUBSTITUTED ANALOGS OF CARBOCYCLIC 3-DEAZAADENOSINE AS POTENTIAL ANTIVIRALS

被引：8

作者：

SECRIST, JA

COMBER, RN

GRAY, RJ

GILROY, RB

MONTGOMERY, JA

机构：

[1] Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255-5305

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 15期

关键词：

D O I：

10.1021/jm00067a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Various 5'-substituted derivatives (2,3,6a, 6b, 9a, 9b, 12,13b, and 15) of carbocyclic 3-deazaadenosine (3-deaza CAdo, 1) were prepared from 3-deaza CAdo (1) and evaluated as antiviral agents against a number of viruses, including HIV-1. Several of the compounds had moderate to good antiviral activity against vaccinia (VV) and vesicular stomatitis (VSV) viruses; however, the antiviral activity of the analogues did not exceed that of the parent compound. No anti-HIV activity was detected.

引用

页码：2102 / 2106

页数：5

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