SYNTHESES OF 5'-SUBSTITUTED ANALOGS OF CARBOCYCLIC 3-DEAZAADENOSINE AS POTENTIAL ANTIVIRALS

被引：8
|
作者：
SECRIST, JA
COMBER, RN
GRAY, RJ
GILROY, RB
MONTGOMERY, JA
机构：
[1] Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255-5305
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 15期
关键词：
D O I：
10.1021/jm00067a008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Various 5'-substituted derivatives (2,3,6a, 6b, 9a, 9b, 12,13b, and 15) of carbocyclic 3-deazaadenosine (3-deaza CAdo, 1) were prepared from 3-deaza CAdo (1) and evaluated as antiviral agents against a number of viruses, including HIV-1. Several of the compounds had moderate to good antiviral activity against vaccinia (VV) and vesicular stomatitis (VSV) viruses; however, the antiviral activity of the analogues did not exceed that of the parent compound. No anti-HIV activity was detected.
引用
收藏
页码：2102 / 2106
页数：5
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