SYNTHESES OF 5'-SUBSTITUTED ANALOGS OF CARBOCYCLIC 3-DEAZAADENOSINE AS POTENTIAL ANTIVIRALS

Various 5'-substituted derivatives (2,3,6a, 6b, 9a, 9b, 12,13b, and 15) of carbocyclic 3-deazaadenosine (3-deaza CAdo, 1) were prepared from 3-deaza CAdo (1) and evaluated as antiviral agents against a number of viruses, including HIV-1. Several of the compounds had moderate to good antiviral activity against vaccinia (VV) and vesicular stomatitis (VSV) viruses; however, the antiviral activity of the analogues did not exceed that of the parent compound. No anti-HIV activity was detected.