N-(3-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine

被引：2

作者：

Uwabagira, Nadine ^{[1
]}

Sarojini, Balladka Kunhana ^{[2
]}

Poojary, Boja ^{[3
]}

机构：

[1] Mangalore Univ, Div Biochem, Dept Studies Chem, Mangalore 574199, Karnataka, India

[2] Mangalore Univ, Dept Studies Ind Chem, Mangalore 574199, Karnataka, India

[3] Mangalore Univ, Dept Studies Chem, Mangalore 574199, Karnataka, India

来源：

MOLBANK | 2018年 / 01期

关键词：

3-chloro-2-methylphenylthiourea; thiazole amine; antibacterial activity;

D O I：

10.3390/M975

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The two precursors 3-chloro-2-methylphenylthiourea 2 and 4-fluorophenacyl bromide 4 are reacted under Hantzsch thiazole synthesis condition to yield the new compound N-(3-chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine 5. The IR, H-1-NMR, C-13-NMR and mass spectral data are presented, along with its in vitro antibacterial activity against Staphylococcus aureus and Chromobacterium violaceum.

引用

页数：5

共 50 条

[31] N-[(9E)-2-chloro-9-thia-9H-xanthen-9-ylidene]-N-(4-fluorophenyl)amine
Chopra, D
Nagarajan, K
Row, TNG
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2004, 60 : O2408 - O2409
[32] 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A):: A potent and selective corticotrophin-releasing factor1 receptor antagonist.: I.: Biochemical and pharmacological characterization
Gully, D
Geslin, M
Serva, L
Fontaine, E
Roger, P
Lair, C
Darre, V
Marcy, C
Rouby, PE
Simiand, J
Guitard, J
Gout, G
Steinberg, R
Rodier, D
Griebel, G
Soubrie, P
Pascal, M
Pruss, R
Scatton, B
Maffrand, JP
Le Fur, G
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 301 (01): : 322 - 332
[33] 4-{1-[4-(4-Bromophenyl)-1,3-thiazol-2yl]-5-(4-fluorophenyl)-4,5-dihydro-1-Hpyrazol-3-yl}-5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazole
Abdel-Wahab, Bakr F.
Mohamed, Hanan A.
Ng, Seik Weng
Tiekink, Edward R. T.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1956 - +
[34] N-[4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Xu, Hong
Sun, Hong-shun
Luo, Feng-mao
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O3432 - U2025
[35] N-(4-Methylphenyl)-3-nitropyridin-2-amine
Akhmad, Mardia Aina Aznan
Abdullah, Zanariah
Fairuz, Zainal A.
Ng, Seik Weng
Tiekink, Edward R. T.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2400 - U1078
[36] Experimental and computational studies on the synthesis and structural characterization of 2-(4-chlorophenoxy)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
Sallam, Hamdi Hamid
Mohammed, Yasser Hussien Issa
Al-Ostoot, Fares Hezam
Akhileshwari, P.
Sridhar, M.A.
Khanum, Shaukath Ara
Journal of Molecular Structure, 2022, 1249
[37] Experimental and computational studies on the synthesis and structural characterization of 2-(4-chlorophenoxy)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
Sallam, Hamdi Hamid
Mohammed, Yasser Hussien Issa
Al-Ostoot, Fares Hezam
Akhileshwari, P.
Sridhar, M. A.
Khanum, Shaukath Ara
JOURNAL OF MOLECULAR STRUCTURE, 2022, 1249
[38] Synthesis, single crystal X-ray, Hirshfeld surface analysis and characterization of novel 4-(2,4-dichloropheny1)-N-(2,6-dichlorophenyl)-1,3-thiazol-2-amine
Gayathri, B. H.
Dasappa, Jagadeesh Prasad
Bhavya, N. R.
Chandra
Mahendra, M.
JOURNAL OF MOLECULAR STRUCTURE, 2017, 1146 : 490 - 498
[39] (4-Fluorophenyl)(2-hydroxy-5-methylphenyl) methanone
Dileep, C. S.
Ranganatha, V. Lakshmi
Lokanath, N. K.
Khanum, S. A.
Sridhar, M. A.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2014, 70 : O286 - +
[40] N-{4-[4-(4-Fluorophenyl)-1-(2-methoxyethyl)-2-methylsulfanyl-1H-imidazol-5-yl]-2-pyridyl}-2-methyl-3-phenylpropionamide
Ziegler, Katharina
Schollmeyer, Dieter
Laufer, Stefan
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O3128 - U914

← 1 2 3 4 5 →