The subcellular localization of 17 beta-hydroxysteroid dehydrogenase type 4 and its interaction with actin

被引：16
|
作者：
Markus, M [1 ]
Husen, B [1 ]
Adamski, J [1 ]
机构：
[1] MAX PLANCK INST EXPTL ENDOCRINOL,D-30625 HANNOVER,GERMANY
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1995年 / 55卷 / 5-6期
关键词：
D O I：
10.1016/0960-0760(95)00213-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The porcine 17 beta-hydroxysteroid dehydrogenase type 4 is the key enzyme for the inactivation of estradiol. Its localization in peroxisomes was proven by immunogold electron microscopy. Interactions of the 17 beta-hydroxysteroid dehydrogenase with cytoskeletal proteins might be mandatory for a topical assignment of enzymatic activity to defined subcellular compartments.
引用
收藏
页码：617 / 621
页数：5
相关论文
共 50 条
  • [31] HYDROXYSTEROID DEHYDROGENASES OF PSEUDOMONAS-TESTOSTERONI - SEPARATION OF A 17BETA-HYDROXYSTEROID DEHYDROGENASE FROM 3(17)BETA-HYDROXYSTEROID DEHYDROGENASE AND COMPARISON OF 2 ENZYMES
    GROMAN, EV
    ENGEL, LL
    BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 485 (02) : 249 - 254
  • [32] PURIFICATION AND PROPERTIES OF A BETA-HYDROXYSTEROID DEHYDROGENASE
    TALALAY, P
    DOBSON, MM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1953, 205 (02) : 823 - 837
  • [33] SITE SPECIFICITY AND MECHANISM OF HUMAN PLACENTAL 17 BETA-HYDROXYSTEROID DEHYDROGENASE
    WARREN, JC
    CRIST, RD
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1967, 118 (03) : 577 - &
  • [34] Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity
    Nokelainen, P
    Puranen, T
    Peltoketo, H
    Orava, M
    Vihko, P
    Vihko, R
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 236 (02): : 482 - 490
  • [35] REGULATION OF OVARIAN 17 BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY BY GONADOTROPIN
    ECKSTEIN, B
    RAVID, R
    BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 627 (02) : 165 - 171
  • [36] Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency
    Andersson, S
    Geissler, WM
    Wu, L
    Davis, DL
    Grumbach, MM
    New, MJ
    Schwarz, HP
    Blethen, SL
    Mendonca, BB
    Bloise, W
    Witchel, SF
    Cutler, GB
    Griffin, JE
    Wilson, JD
    Russell, DW
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (01): : 130 - 136
  • [37] Difference in expression of 17 beta-hydroxysteroid dehydrogenase type 1 in uterine fibroid and normal myometrium
    Siregar, M. F. G.
    Arthit, T. L.
    Munthe, I. G.
    Haryono, H. L.
    Sidabutar, E.
    Rivany, R.
    GIORNALE ITALIANO DI OSTETRICIA E GINECOLOGIA, 2018, 40 (04): : 172 - 177
  • [38] 17 BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN HUMAN AMNIOTIC EPITHELIUM
    SULCOVA, J
    JIRASEK, JE
    STARKA, L
    ENDOKRINOLOGIE, 1974, 63 (02): : 249 - 253
  • [39] The 11 beta-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action - Role of type-1 11 beta-hydroxysteroid dehydrogenase in detoxification processes
    Maser, E
    Oppermann, UCT
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 249 (02): : 365 - 369
  • [40] Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol
    Azzi, A
    Rehse, PH
    Zhu, DW
    Campbell, RL
    Labrie, F
    Lin, SX
    NATURE STRUCTURAL BIOLOGY, 1996, 3 (08): : 665 - 668
12345