DETERMINATION OF THE CALCIUM-ANTAGONIST SIM6080 IN PLASMA BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY

被引：2
|
作者：
CASTELNOVO, P
机构：
[1] Drug Discovery Analysis Group, Zambon Research s.p.a., 20091 Bresso-Milan
来源：
JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1994年 / 652卷 / 02期
关键词：
D O I：
10.1016/0378-4347(93)E0401-B
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A sensitive and selective gas chromatographic method for the determination of the calcium antagonist SIM6080 in plasma has been developed and validated. A three-step extraction procedure is employed followed by capillary gas chromatographic analysis using nitrogen-selective detection and the programmed temperature vaporizer injection technique. The defluorinated analogue was used as the internal standard. The analysis of spiked plasma demonstrated the good accuracy and precision of the method with limit of detection of 1 ng/ml. The method has been used for pharmacokinetic studies in laboratory animals.
引用
收藏
页码：240 / 244
页数：5
相关论文
共 50 条
  • [41] ANALYSIS OF COMPLEX NATURAL SAMPLES BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY
    REED, WE
    STUERMER, DH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1977, 174 (SEP): : 25 - 25
  • [42] DETERMINATION OF SULFUR COMPONENTS IN LIGHT PETROLEUM STREAMS BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY WITH CHEMILUMINESCENCE DETECTION
    CHAWLA, B
    DISANZO, F
    JOURNAL OF CHROMATOGRAPHY, 1992, 589 (1-2): : 271 - 279
  • [43] DETERMINATION OF 2 URINARY PROSTAGLANDINS BY CAPILLARY GAS-CHROMATOGRAPHY HIGH-RESOLUTION MASS-SPECTROMETRY
    HEROLD, DA
    SAVORY, J
    KINTER, M
    ROSS, R
    WILLS, MR
    CLINICAL CHEMISTRY, 1987, 33 (06) : 891 - 891
  • [44] CHARACTERIZATION AND DETERMINATION OF PCB ISOMERS BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY AND HRGC MASS-SPECTROMETRY
    ONUSKA, FI
    TERRY, KA
    JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY & CHROMATOGRAPHY COMMUNICATIONS, 1986, 9 (11): : 671 - 675
  • [45] DETERMINATION OF ATRAZINE AND SIMAZINE IN ESTUARINE SAMPLES BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY AND NITROGEN SELECTIVE DETECTION
    AHEL, M
    EVANS, KM
    FILEMAN, TW
    MANTOURA, RFC
    ANALYTICA CHIMICA ACTA, 1992, 268 (02) : 195 - 204
  • [46] FAST DETERMINATION OF SOME HALOCARBONS IN THE ATMOSPHERE BY GAS-CHROMATOGRAPHY HIGH-RESOLUTION MASS-SPECTROMETRY
    CRESCENTINI, G
    MANGANI, F
    MASTROGIACOMO, AR
    CAPPIELLO, A
    BRUNER, F
    JOURNAL OF CHROMATOGRAPHY, 1983, 280 (01): : 146 - 151
  • [47] SIMULTANEOUS DETERMINATION OF MULTIPLE TESTICULAR STEROIDS UTILIZING HIGH-RESOLUTION GLASS CAPILLARY GAS-CHROMATOGRAPHY
    HILTON, LL
    WOHLEB, RH
    FREE, MJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1977, 174 (SEP): : 19 - 19
  • [48] Determination of Oligosaccharides by Conventional High-Resolution Gas Chromatography
    A. Montilla
    J. van de Lagemaat
    A. Olano
    M. D. del Castillo
    Chromatographia, 2006, 63 : 453 - 458
  • [49] Determination of oligosaccharides by conventional high-resolution gas chromatography
    Montilla, A.
    van de Lagemaat, J.
    Olano, A.
    del Castillo, M. D.
    CHROMATOGRAPHIA, 2006, 63 (9-10) : 453 - 458
  • [50] HOMOLOG DISTRIBUTIONS OF POLYCHLORINATED TERPHENYLS BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY AND HIGH-RESOLUTION MASS-SPECTROMETRY
    CAIXACH, J
    RIVERA, J
    GALCERAN, MT
    SANTOS, FJ
    JOURNAL OF CHROMATOGRAPHY A, 1994, 675 (1-2) : 205 - 211
12345