DETERMINATION OF THE CALCIUM-ANTAGONIST SIM6080 IN PLASMA BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY

被引：2
|
作者：
CASTELNOVO, P
机构：
[1] Drug Discovery Analysis Group, Zambon Research s.p.a., 20091 Bresso-Milan
来源：
JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1994年 / 652卷 / 02期
关键词：
D O I：
10.1016/0378-4347(93)E0401-B
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A sensitive and selective gas chromatographic method for the determination of the calcium antagonist SIM6080 in plasma has been developed and validated. A three-step extraction procedure is employed followed by capillary gas chromatographic analysis using nitrogen-selective detection and the programmed temperature vaporizer injection technique. The defluorinated analogue was used as the internal standard. The analysis of spiked plasma demonstrated the good accuracy and precision of the method with limit of detection of 1 ng/ml. The method has been used for pharmacokinetic studies in laboratory animals.
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页码：240 / 244
页数：5
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