Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs

被引：12
|
作者：
Rajput, Chatrasal Singh [1 ,2 ]
Singhal, Shiwani [1 ]
机构：
[1] LLRM Med Coll, Dept Pharmacol, Div Med Chem, Meerut 250002, Uttar Pradesh, India
[2] Jubilant Chemsys Ltd, R&D B-34,Sect 58, Noida 201301, India
来源：
JOURNAL OF PHARMACEUTICS | 2013年 / 2013卷
关键词：
D O I：
10.1155/2013/907525
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of 3-[2'-(Substitutedbenzylideneamino)phenyll-2-methy1-6-substituted quinazolin-4-ones (5-10), 3-[2'-(3 ''-chloro-2 '' oxo-4 ''-substitutedphenylazetidin-1 ''-yl)phenyll-2-methy1-6-stibstituted quinazolin-4-ones (11-16), and 3-[2'-(2 ''-substitutedpheny1-4 ''-oxo-1,3 ''-thiazolidin-3 ''-yl)phentl]-2-methy1-6-substitutedquinazolin-4-ones (17-22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H-1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic activities.
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页数：7
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