Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs

A series of 3-[2'-(Substitutedbenzylideneamino)phenyll-2-methy1-6-substituted quinazolin-4-ones (5-10), 3-[2'-(3 ''-chloro-2 '' oxo-4 ''-substitutedphenylazetidin-1 ''-yl)phenyll-2-methy1-6-stibstituted quinazolin-4-ones (11-16), and 3-[2'-(2 ''-substitutedpheny1-4 ''-oxo-1,3 ''-thiazolidin-3 ''-yl)phentl]-2-methy1-6-substitutedquinazolin-4-ones (17-22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H-1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic activities.