1-ALPHA,25-DIHYDROXYVITAMIN-D-3 HYBRID ANALOGS WITH STRUCTURAL-CHANGES AT BOTH THE A-RING AND THE C,D-RING SIDE-CHAIN .2.

被引：18
|
作者：
POSNER, GH
LEE, JK
LI, ZG
TAKEUCHI, K
GUGGINO, SE
DOLAN, P
KENSLER, TW
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21218
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21218
[3] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,DIV TOXICOL SCI,BALTIMORE,MD 21218
[4] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,ENVIRONM HLTH SCI CTR,BALTIMORE,MD 21218
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 18期
关键词：
D O I：
10.1016/0960-894X(95)00376-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (+/-)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities.
引用
收藏
页码：2163 / 2168
页数：6
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