1-ALPHA,25-DIHYDROXYVITAMIN-D-3 HYBRID ANALOGS WITH STRUCTURAL-CHANGES AT BOTH THE A-RING AND THE C,D-RING SIDE-CHAIN .2.

被引：18

作者：

POSNER, GH

LEE, JK

LI, ZG

TAKEUCHI, K

GUGGINO, SE

DOLAN, P

KENSLER, TW

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21218

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21218

[3] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,DIV TOXICOL SCI,BALTIMORE,MD 21218

[4] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,ENVIRONM HLTH SCI CTR,BALTIMORE,MD 21218

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 18期

关键词：

D O I：

10.1016/0960-894X(95)00376-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (+/-)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities.

引用

页码：2163 / 2168

页数：6

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