DEVELOPMENT OF A MOUSE MODEL OF HELICOBACTER-PYLORI INFECTION THAT MIMICS HUMAN-DISEASE

被引：509
|
作者：
MARCHETTI, M
ARICO, B
BURRONI, D
FIGURA, N
RAPPUOLI, R
GHIARA, P
机构：
[1] BIOCINE SPA, IMMUNOBIOL RES INST SIENA, I-53100 SIENA, ITALY
[2] UNIV SIENA, IST PATOL SPECIALE MED, I-53100 SIENA, ITALY
来源：
SCIENCE | 1995年 / 267卷 / 5204期
关键词：
D O I：
10.1126/science.7886456
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections With cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected mice from bacterial infection. This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans.
引用
收藏
页码：1655 / 1658
页数：4
相关论文
共 50 条
  • [41] DIAGNOSIS OF HELICOBACTER-PYLORI INFECTION
    BROWN, KE
    PEURA, DA
    GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 1993, 22 (01) : 105 - 115
  • [42] SOURCE OF HELICOBACTER-PYLORI INFECTION
    VAIRA, D
    MENEGATTI, M
    MIGLIOLI, M
    BARBARA, L
    HOLTON, J
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 1993, 88 (08): : 1297 - 1297
  • [43] HELICOBACTER-PYLORI INFECTION AND INFLAMMATION
    HEATLEY, RV
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1991, 26 : 23 - 30
  • [44] HELICOBACTER-PYLORI INFECTION IN CHILDREN
    HARDIKAR, W
    DAVIDSON, PM
    CAMERON, DJS
    GILBERT, GL
    CAMPBELL, PE
    SMITH, AL
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1991, 6 (05) : 450 - 454
  • [45] SEROLOGY IN HELICOBACTER-PYLORI INFECTION
    GLUPCZYNSKI, Y
    GOOSSENS, H
    BURETTE, A
    DEPREZ, C
    VANBORRE, C
    BUTZLER, JP
    ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES, 1993, 280 (1-2): : 150 - 154
  • [46] ANIMAL-MODEL OF HELICOBACTER-PYLORI INFECTION - REPLY
    WESTBLOM, TU
    BELSHE, RB
    MADAN, E
    DURIEX, DE
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (07) : 1462 - 1462
  • [47] EVALUATION OF NEW THERAPY FOR ERADICATION OF HELICOBACTER-PYLORI INFECTION IN NUDE-MOUSE MODEL
    KARITA, M
    LI, Q
    OKITA, K
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 1993, 88 (09): : 1366 - 1372
  • [48] ESTABLISHMENT OF A SMALL ANIMAL-MODEL FOR HUMAN HELICOBACTER-PYLORI INFECTION USING GERM-FREE MOUSE
    KARITA, M
    LI, Q
    CANTERO, D
    OKITA, K
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 1994, 89 (02): : 208 - 213
  • [49] CAGA EXPRESSION IN HELICOBACTER-PYLORI (HELICOBACTER-PYLORI) RELATED GASTRODUODENAL DISEASE
    PATCHETT, SE
    KATELARIS, PH
    LIN, L
    WILKS, M
    ZHANG, ZW
    DOMIZIO, P
    FARTHING, MJG
    TABAQCHALI, S
    GASTROENTEROLOGY, 1995, 108 (04) : A187 - A187
  • [50] THE ROLE AND TREATMENT OF HELICOBACTER-PYLORI INFECTION IN PEPTIC-ULCER DISEASE - A REVIEW OF THE RELATIONSHIP BETWEEN HELICOBACTER-PYLORI INFECTION AND PEPTIC-ULCER DISEASE
    FLETCHER, PJ
    CRAIG, DQM
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 1993, 18 (05) : 311 - 316
12345