DEVELOPMENT OF A MOUSE MODEL OF HELICOBACTER-PYLORI INFECTION THAT MIMICS HUMAN-DISEASE

被引：509
|
作者：
MARCHETTI, M
ARICO, B
BURRONI, D
FIGURA, N
RAPPUOLI, R
GHIARA, P
机构：
[1] BIOCINE SPA, IMMUNOBIOL RES INST SIENA, I-53100 SIENA, ITALY
[2] UNIV SIENA, IST PATOL SPECIALE MED, I-53100 SIENA, ITALY
来源：
SCIENCE | 1995年 / 267卷 / 5204期
关键词：
D O I：
10.1126/science.7886456
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections With cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected mice from bacterial infection. This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans.
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页码：1655 / 1658
页数：4
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