Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

被引：3
|
作者：
Yamada, Shunsuke [1 ,2 ]
Tokumoto, Masanori [2 ]
Taniguchi, Masatomo [1 ]
Kitada, Hidehisa [3 ]
Tsuruya, Kazuhiko [1 ,4 ]
Kitazono, Takanari [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan
[2] Fukuoka Dent Coll, Div Internal Med, Fukuoka, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan
[4] Kyushu Univ, Grad Sch Med Sci, Dept Integrated Therapy Chron Kidney Dis, Fukuoka, Japan
来源：
CLINICAL KIDNEY JOURNAL | 2013年 / 6卷 / 04期
关键词：
calcium-sensing receptor; N-terminus PTH; parafibromin; secondary hyperparathyroidism;
D O I：
10.1093/ckj/sft061
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.
引用
收藏
页码：429 / 432
页数：4
相关论文
共 50 条
  • [31] Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function
    Ritter, CS
    Martin, DR
    Lu, Y
    Slatopolsky, E
    Brown, AJ
    JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (12) : 2206 - 2213
  • [32] Calcium-sensing receptor regulation of PTH-dependent calcium absorption by mouse cortical ascending limbs
    Motoyama, HI
    Friedman, PA
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2002, 283 (03) : F399 - F406
  • [33] Amino terminal cleavage of PTH(1–84) to PTH(7–84) is regulated by serum calcium concentration via calcium-sensing receptor in hemodialysis patients
    Masao Koshikawa
    Kensuke Nishiguchi
    Soshi Yorifuji
    Keiji Shimazu
    Koji Takaori
    Keita Mori
    Eriko Eguchi
    Kikuo Okada
    Atsuo Tanaka
    Takashi Kuwahara
    Clinical and Experimental Nephrology, 2010, 14 : 233 - 238
  • [34] Comparative messenger RNA expression analysis of vitamin D receptor, calcium-sensing receptor, cyclin D1, and PTH in symptomatic and asymptomatic primary hyperparathyroidism in Asian Indians
    Hegde, Dwijaraj
    Kaur, Parjeet
    Mishra, Sunil
    Sarin, Deepak
    Gautam, Dheeraj
    Singh, Priyanka
    Bhadada, Sanjay
    Mithal, Ambrish
    JOURNAL OF BONE AND MINERAL RESEARCH, 2020, 35 : 135 - 135
  • [35] Whole PTH assay does not provide better discrimination than the intact PTH in patients with secondary hyperparathyroidism due to renal failure or vitamin D deficiency.
    Glendenning, P
    Laffer, LLA
    Musk, AA
    Vasikaran, SD
    JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 : S285 - S285
  • [36] Amino terminal cleavage of PTH(1-84) to PTH(7-84) is regulated by serum calcium concentration via calcium-sensing receptor in hemodialysis patients
    Koshikawa, Masao
    Nishiguchi, Kensuke
    Yorifuji, Soshi
    Shimazu, Keiji
    Takaori, Koji
    Mori, Keita
    Eguchi, Eriko
    Okada, Kikuo
    Tanaka, Atsuo
    Kuwahara, Takashi
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2010, 14 (03) : 233 - 238
  • [37] Novel Gain of Function Mutations of the Calcium-sensing Receptor in Two Patients with PTH-deficient Hypocalcemia
    Nakajima, Kishiko
    Yamazaki, Kazuko
    Kimura, Hironari
    Takano, Kazue
    Miyoshi, Hitoshi
    Sato, Kanji
    INTERNAL MEDICINE, 2009, 48 (22) : 1951 - +
  • [38] A Novel Variant in the Calcium-Sensing Receptor Associated with Familial Hypocalciuric Hypercalcemia and Low-to-Normal PTH
    Majumdar, Sachin K.
    Jacob, Tess
    Bale, Allen
    Bailey, Allison
    Kwon, Jeffrey
    Hughes, Terence
    Barbieri, Andrea L.
    Laskin, William
    Cohen, Paul
    Carling, Tobias John Eric
    CASE REPORTS IN ENDOCRINOLOGY, 2020, 2020
  • [39] Expression of the Calcium-Sensing Receptor on Normal and Abnormal Parathyroid and Thyroid Tissue
    Worth, Anne L.
    Ayrapetyan, Mesrop
    Maygarden, Susan J.
    Li, Zibo
    Wu, Zhanhong
    Agala, Chris B.
    Kim, Lawrence T.
    JOURNAL OF SURGICAL RESEARCH, 2024, 293 : 618 - 624
  • [40] PTH/PTHRP RECEPTOR MESSENGER-RNA EXPRESSION AND PTH RESPONSE IN A RAT MODEL OF SECONDARY HYPERPARATHYROIDISM ASSOCIATED WITH VITAMIN-D DEFICIENCY
    TURNER, G
    COUREAU, C
    RABIN, MR
    ESCOUBET, B
    HRUBY, M
    WALRANT, O
    SILVE, C
    JOURNAL OF BONE AND MINERAL RESEARCH, 1995, 10 : S277 - S277
12345