Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

被引：3
|
作者：
Yamada, Shunsuke [1 ,2 ]
Tokumoto, Masanori [2 ]
Taniguchi, Masatomo [1 ]
Kitada, Hidehisa [3 ]
Tsuruya, Kazuhiko [1 ,4 ]
Kitazono, Takanari [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan
[2] Fukuoka Dent Coll, Div Internal Med, Fukuoka, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan
[4] Kyushu Univ, Grad Sch Med Sci, Dept Integrated Therapy Chron Kidney Dis, Fukuoka, Japan
来源：
CLINICAL KIDNEY JOURNAL | 2013年 / 6卷 / 04期
关键词：
calcium-sensing receptor; N-terminus PTH; parafibromin; secondary hyperparathyroidism;
D O I：
10.1093/ckj/sft061
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.
引用
收藏
页码：429 / 432
页数：4
相关论文
共 50 条
  • [21] The role of calcium-sensing receptor abnormality in the pathogenesis of secondary hyperparathyroidism
    Akizawa, T
    Ogata, H
    Koiwa, F
    Kinugasa, E
    Ideura, T
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 : 66 - 67
  • [22] Fluoride Affects Calcium Homeostasis by Regulating Parathyroid Hormone, PTH-Related Peptide, and Calcium-Sensing Receptor Expression
    Ying Wang
    Xiao-qin Duan
    Zhi-tao Zhao
    Xiu-yun Zhang
    Huan Wang
    Da-wei Liu
    Guang-sheng Li
    Ling Jing
    Biological Trace Element Research, 2015, 165 : 159 - 166
  • [23] Fluoride Affects Calcium Homeostasis by Regulating Parathyroid Hormone, PTH-Related Peptide, and Calcium-Sensing Receptor Expression
    Wang, Ying
    Duan, Xiao-qin
    Zhao, Zhi-tao
    Zhang, Xiu-yun
    Wang, Huan
    Liu, Da-wei
    Li, Guang-sheng
    Jing, Ling
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2015, 165 (02) : 159 - 166
  • [24] Restoration of reversed whole PTH/intact PTH ratio and reduction in parathyroid gland vascularity during cinacalcet therapy for severe hyperparathyroidism in a uraemic patient
    Komaba, Hirotaka
    Shin, Jeongsoo
    Fukagawa, Masafumi
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (02) : 638 - 641
  • [25] The calcium-sensing receptor and vitamin D receptor expression in tertiary hyperparathyroidism
    Grzela, T
    Chudzinski, W
    Lasiecka, Z
    Niderla, J
    Wilczynski, G
    Gornicka, B
    Wasiutynski, A
    Durlik, M
    Boszczyk, A
    Brawura-Biskupski-Samaha, R
    Dziunycz, P
    Milewski, L
    Lazarczyk, M
    Lazarczyk, M
    Nawrot, I
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2006, 17 (05) : 779 - 783
  • [26] Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport
    Ba, JM
    Brown, D
    Friedman, PA
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 285 (06) : F1233 - F1243
  • [27] Roles of Calcium-Sensing Receptor and Vitamin D Receptor in the Pathophysiology of Secondary Hyperparathyroidism
    McCann, Linda M.
    Beto, Judith
    JOURNAL OF RENAL NUTRITION, 2010, 20 (03) : 141 - 150
  • [28] Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism
    Lee, Hye-Jeong
    Seo, U-Hyoung
    Kim, Woo-Young
    Woo, Sang-Uk
    Lee, Jae-Bok
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2013, 41 (01) : 97 - 105
  • [29] Primary and secondary hyperparathyroidism present different expressions of calcium-sensing receptor
    Xin Li
    Yao Lu
    Ling Zhang
    Aiping Song
    Honglei Zhang
    Bo Pang
    Jun Liu
    Xiaoliang Sun
    Haoyang Ji
    Linping Huang
    Meng Yang
    BMC Surgery, 23
  • [30] Primary and secondary hyperparathyroidism present different expressions of calcium-sensing receptor
    Li, Xin
    Lu, Yao
    Zhang, Ling
    Song, Aiping
    Zhang, Honglei
    Pang, Bo
    Liu, Jun
    Sun, Xiaoliang
    Ji, Haoyang
    Huang, Linping
    Yang, Meng
    BMC SURGERY, 2023, 23 (01)
12345