EFFECTS OF TREATMENT WITH SIMVASTATIN AND PRAVASTATIN ON COGNITIVE FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA

被引：41
|
作者：
CUTLER, N
SRAMEK, J
VEROFF, A
BLOCK, G
STAUFFER, L
LINES, C
机构：
[1] CALIF CLIN TRIALS,BEVERLY HILLS,CA 90211
[2] MERCK SHARP & DOHME LTD,RES LABS,BLUE BELL,PA 19422
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 39卷 / 03期
关键词：
SIMVASTATIN; PRAVASTATIN; CHOLESTEROL; COGNITIVE FUNCTION;
D O I：
10.1111/j.1365-2125.1995.tb04458.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day(-1)) and pravastatin (40 mg day(-1)) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.
引用
收藏
页码：333 / 336
页数：4
相关论文
共 50 条
  • [41] Combined treatment with captopril and pravastatin in essential hypertensive patients with hypercholesterolemia.
    Luque, M
    HYPERTENSION, 1997, 29 (03) : 125 - 125
  • [42] Significant differential metabolic effects of simvastatin combined with ezetimibe and simvastatin alone in patients with hypercholesterolemia
    Koh, K.
    EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING, 2015, 14 : S25 - S25
  • [43] No effect of simvastatin treatment on insulin sensitivity in patients with primary hypercholesterolemia
    Altunbas, H
    Balci, MK
    Karayalçin, Ü
    ENDOCRINE RESEARCH, 2003, 29 (03) : 265 - 275
  • [44] EFFECT OF PRAVASTATIN TREATMENT ON GLUCOSE, INSULIN, AND LIPOPROTEIN METABOLISM IN PATIENTS WITH HYPERCHOLESTEROLEMIA
    SHEU, WHH
    SHIEH, SM
    SHEN, DDC
    FUH, MMT
    JENG, CY
    CHEN, YDI
    REAVEN, GM
    AMERICAN HEART JOURNAL, 1994, 127 (02) : 331 - 336
  • [45] Vascular and metabolic effects of ezetimibe combined with simvastatin in patients with hypercholesterolemia
    Koh, Kwang Kon
    Oh, Pyung Chun
    Sakuma, Ichiro
    Kim, Eun Young
    Lee, Yonghee
    Hayashi, Toshio
    Han, Seung Hwan
    Park, Yae Min
    Shin, Eak Kyun
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2015, 199 : 126 - 131
  • [46] Effects of ezetimibe/simvastatin on lipoprotein subclasses in patients with primary hypercholesterolemia
    Ose, L.
    Olegario, K. Q.
    Reyes, R.
    Johnson-Levonas, A. O.
    Sapre, A.
    Tribble, D.
    EUROPEAN HEART JOURNAL, 2006, 27 : 945 - 945
  • [47] COMPARATIVE EFFICACY AND TOLERABILITY OF 5 AND 10 MG SIMVASTATIN AND 10 MG PRAVASTATIN IN MODERATE PRIMARY HYPERCHOLESTEROLEMIA - SIMVASTATIN PRAVASTATIN EUROPEAN STUDY-GROUP
    STEINHAGENTHIESSEN, E
    CARDIOLOGY, 1994, 85 (3-4) : 244 - 254
  • [48] Effects of pravastatin on thoracic aortic atherosclerosis in patients with heterozygous familial hypercholesterolemia
    Pitsavos, CE
    Aggeli, KI
    Barbetseas, JD
    Skoumas, IN
    Lambrou, SG
    Frogoudaki, AA
    Stefanadis, CI
    Toutouzas, PK
    AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (12): : 1484 - 1488
  • [49] COMPARISON OF THE EFFECTS OF PRAVASTATIN AND SIMVASTATIN IN HYPERCHOLESTEROLEMIC SUBJECTS
    YOSHINO, G
    KAZUMI, T
    MATSUSHITA, M
    IWAI, M
    MATSUBA, K
    MORITA, M
    YOSHIDA, M
    BABA, S
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1990, 48 (02): : 259 - 267
  • [50] EFFICACY AND TOLERABILITY OF SIMVASTATIN 20-MG VS PRAVASTATIN 20-MG IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA
    LAMBRECHT, LJ
    MALINI, PL
    ACTA CARDIOLOGICA, 1993, 48 (06) : 541 - 554
12345