EFFECTS OF TREATMENT WITH SIMVASTATIN AND PRAVASTATIN ON COGNITIVE FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA

被引：41
|
作者：
CUTLER, N
SRAMEK, J
VEROFF, A
BLOCK, G
STAUFFER, L
LINES, C
机构：
[1] CALIF CLIN TRIALS,BEVERLY HILLS,CA 90211
[2] MERCK SHARP & DOHME LTD,RES LABS,BLUE BELL,PA 19422
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 39卷 / 03期
关键词：
SIMVASTATIN; PRAVASTATIN; CHOLESTEROL; COGNITIVE FUNCTION;
D O I：
10.1111/j.1365-2125.1995.tb04458.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day(-1)) and pravastatin (40 mg day(-1)) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.
引用
收藏
页码：333 / 336
页数：4
相关论文
共 50 条
  • [21] Effects of simvastatin, ezetimibe and simvastatin/ezetimibe on mitochondrial function and leukocyte/endothelial cell interactions in patients with hypercholesterolemia
    Hernandez-Mijares, Antonio
    Banuls, Celia
    Rovira-Llopis, Susana
    Diaz-Morales, Noelia
    Escribano-Lopez, Irene
    de Pablo, Carmen
    Alvarez, Angeles
    Veses, Silvia
    Rocha, Milagros
    Victor, Victor M.
    ATHEROSCLEROSIS, 2016, 247 : 40 - 47
  • [22] Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients
    Koh, Kwang Kon
    Quon, Michael J.
    Han, Seung Hwan
    Lee, Yonghee
    Kim, Soo Jin
    Park, Jeong Beorn
    Shin, Eak Kyun
    ATHEROSCLEROSIS, 2009, 204 (02) : 483 - 490
  • [23] SIMVASTATIN IN THE TREATMENT OF ELDERLY PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA
    GIANNINI, SD
    DEGOES, JM
    DEREVIACKI, BE
    MACHADO, C
    FORTI, N
    DIAMENT, J
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1994, 55 (02): : 161 - 171
  • [24] EFFICACY AND TOLERABILITY OF SIMVASTATIN AND PRAVASTATIN IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA (MULTICOUNTRY COMPARATIVE-STUDY)
    LEFEBVRE, P
    SCHEEN, A
    MATERNE, P
    POPEYE, R
    QUOIDBACH, A
    BERCOVICI, JP
    CHADENAS, D
    DEVULDER, B
    DOUSTEBLAZY, P
    LOUVET, JP
    FARNIER, M
    GANCEL, A
    HAUTECOUVERTURE, M
    PINGET, M
    ROGER, P
    VAGUE, P
    FEELY, J
    FENNELL, W
    TOMKIN, G
    MALINI, PL
    STROCCHI, E
    DEDIVITIIS, O
    DISOMMA, S
    ROSIELLO, G
    TRIMARCO, B
    LANSBERG, PJ
    KASTELEIN, JJP
    AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (15): : 1281 - 1286
  • [25] TREATMENT OF HYPERCHOLESTEROLEMIA WITH SIMVASTATIN
    ACHTEN, B
    PERFUSION, 1992, 5 (04): : 120 - 121
  • [26] COMPARATIVE EFFECTS OF SIMVASTATIN AND LOVASTATIN IN PATIENTS WITH HYPERCHOLESTEROLEMIA
    FARMER, JA
    WASHINGTON, LC
    JONES, PH
    SHAPIRO, DR
    GOTTO, AM
    MANTELL, G
    CLINICAL THERAPEUTICS, 1992, 14 (05) : 708 - 717
  • [27] SIMVASTATIN AND PRAVASTATIN - A DAILY DOSE OF 40 MG IN THE LONG-TERM TREATMENT OF PRIMARY HYPERCHOLESTEROLEMIA
    STEFANUTTI, C
    VIVENZIO, A
    LUCANI, G
    DIGIACOMO, S
    COLOMBO, C
    BIANCHI, MA
    RICCI, G
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1994, 55 (04): : 446 - 454
  • [28] Significant Differential Metabolic Effects of Pravastatin and Simvastatin In Hypercholesterolemic Patients
    Koh, Kwang K.
    Quon, Michael J.
    Han, Seung H.
    Chung, Wook-Jin
    Shin, Eak K.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (10) : A428 - A428
  • [29] HYPERCHOLESTEROLEMIA - SIMVASTATIN AND PRAVASTATIN ALTER CHOLESTEROL-METABOLISM BY DIFFERENT MECHANISMS
    OWENS, D
    COLLINS, P
    JOHNSON, A
    TIGHE, O
    ROBINSON, K
    TOMKIN, GH
    BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1082 (03) : 303 - 309
  • [30] SIMVASTATIN IN THE TREATMENT OF HYPERCHOLESTEROLEMIA IN PATIENTS WITH ESSENTIAL-HYPERTENSION
    MORGAN, T
    ANDERSON, A
    MCDONALD, P
    HOPPER, J
    MACASKILL, G
    JOURNAL OF HYPERTENSION, 1990, 8 : S25 - S32
12345