OnabotulinumtoxinA (BOTOX®)A Review of its Use in the Prophylaxis of Headaches in Adults with Chronic Migraine

被引：0
|
作者：
James E. Frampton
机构：
[1] Adis,
来源：
Drugs | 2012年 / 72卷
关键词：
Migraine; Topiramate; Chronic Migraine; Medication Overuse; OnabotulinumtoxinA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This article reviews the pharmacology, therapeutic efficacy and tolerability profile of intramuscularly injected onabotulinumtoxinA (onaBoNTA; BOTOX®) for headache prophylaxis in adults with chronic migraine, with a focus on UK labelling for the drug. The pharmacological actions of onaBoNTA include a direct antinociceptive (analgesic) effect; while not fully understood, the mechanism of action underlying its headache prophylaxis effect in chronic migraine is presumed to involve inhibition of peripheral and central sensitization in trigemino-vascular neurones.
引用
收藏
页码：825 / 845
页数：20
相关论文
共 50 条
  • [31] THE REAL-WORLD EFFICACY OF BOTULINUM TOXIN TYPE A (BOTOX®) FOR THE PROPHYLAXIS OF HEADACHES IN ADULT PATIENTS WITH CHRONIC MIGRAINE IN AUSTRALIAN CLINICAL PRACTICE: A RETROSPECTIVE CHART REVIEW
    Stark, Catherine
    Stark, Richard
    Limberg, Nicole
    Andrews, Colin
    Rodrigues, Julian
    Cordato, Dennis
    Schwartz, Raymond
    Michelle, Frost J.
    Jonathan, Tan
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2017, 88 (05):
  • [32] Economic consequences of migraine in Sweden and implications for the cost-effectiveness of onabotulinumtoxinA (Botox) for chronic migraine in Sweden and Norway
    Hansson-Hedblom, Amanda
    Axelsson, Isabelle
    Jacobson, Lena
    Tedroff, Joakim
    Borgstrom, Fredrik
    JOURNAL OF HEADACHE AND PAIN, 2020, 21 (01):
  • [33] Economic consequences of migraine in Sweden and implications for the cost-effectiveness of onabotulinumtoxinA (Botox) for chronic migraine in Sweden and Norway
    Amanda Hansson-Hedblom
    Isabelle Axelsson
    Lena Jacobson
    Joakim Tedroff
    Fredrik Borgström
    The Journal of Headache and Pain, 2020, 21
  • [34] Review: Prophylactic botulinum toxin A reduces frequency of chronic migraine headaches in adults
    Badgett, Robert
    Massey, Andrew
    ANNALS OF INTERNAL MEDICINE, 2012, 157 (04)
  • [35] Dispute settlement understanding on the use of BOTOX® in chronic migraine
    Martelletti, Paolo
    JOURNAL OF HEADACHE AND PAIN, 2011, 12 (01): : 1 - 2
  • [36] Dispute settlement understanding on the use of BOTOX® in chronic migraine
    Paolo Martelletti
    The Journal of Headache and Pain, 2011, 12 : 1 - 2
  • [37] Rationale for use of onabotulinum toxin A (BOTOX) in chronic migraine
    P. Barbanti
    G. Egeo
    L. Fofi
    C. Aurilia
    S. Piroso
    Neurological Sciences, 2015, 36 : 29 - 32
  • [38] Rationale for use of onabotulinum toxin A (BOTOX) in chronic migraine
    Barbanti, P.
    Egeo, G.
    Fofi, L.
    Aurilia, C.
    Piroso, S.
    NEUROLOGICAL SCIENCES, 2015, 36 : S29 - S32
  • [39] Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review
    Burstein, Rami
    Blumenfeld, Andrew M.
    Silberstein, Stephen D.
    Adams, Aubrey Manack
    Brin, Mitchell F.
    HEADACHE, 2020, 60 (07): : 1259 - 1272
  • [40] OnabotulinumtoxinA in Chronic Migraine: A Profile of Its Use (vol 34, pg 1287, 2020)
    Frampton, James E.
    CNS DRUGS, 2021, 35 (06) : 701 - 701
12345