OnabotulinumtoxinA (BOTOX®)A Review of its Use in the Prophylaxis of Headaches in Adults with Chronic Migraine

被引：0
|
作者：
James E. Frampton
机构：
[1] Adis,
来源：
Drugs | 2012年 / 72卷
关键词：
Migraine; Topiramate; Chronic Migraine; Medication Overuse; OnabotulinumtoxinA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This article reviews the pharmacology, therapeutic efficacy and tolerability profile of intramuscularly injected onabotulinumtoxinA (onaBoNTA; BOTOX®) for headache prophylaxis in adults with chronic migraine, with a focus on UK labelling for the drug. The pharmacological actions of onaBoNTA include a direct antinociceptive (analgesic) effect; while not fully understood, the mechanism of action underlying its headache prophylaxis effect in chronic migraine is presumed to involve inhibition of peripheral and central sensitization in trigemino-vascular neurones.
引用
收藏
页码：825 / 845
页数：20
相关论文
共 50 条
  • [21] OnabotulinumtoxinA: A Review in the Prevention of Chronic Migraine
    James E. Frampton
    Stephen Silberstein
    Drugs, 2018, 78 : 589 - 600
  • [22] Homeopathic prophylaxis of headaches and migraine? A systematic review
    Ernst, E
    JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 1999, 18 (05) : 353 - 357
  • [23] Treatment of chronic refractory migraine with onabotulinumtoxina (botox®) according to the preeempt clinical program
    Ferrandi, D.
    Prevost, C.
    Dell'Acqua, M. L.
    Ursino, G.
    Ursino, E.
    Ruiz, L.
    NEUROLOGICAL SCIENCES, 2011, 32 : S205 - S205
  • [24] Prophylaxis of migraine headaches with riboflavin: A systematic review
    Thompson, D. F.
    Saluja, H. S.
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2017, 42 (04) : 394 - 403
  • [25] A Randomized Trial to Evaluate OnabotulinumtoxinA for Prevention of Headaches in Adolescents With Chronic Migraine
    Winner, Paul K.
    Kabbouche, Marielle
    Yonker, Marcy
    Wangsadipura, Veronica
    Lum, Arlene
    Brin, Mitchell F.
    HEADACHE, 2020, 60 (03): : 564 - 575
  • [26] Real-world effectiveness of onabotulinumtoxinA treatment for the prevention of headaches in adults with chronic migraine in Australia: a retrospective study
    Catherine Stark
    Richard Stark
    Nicole Limberg
    Julian Rodrigues
    Dennis Cordato
    Raymond Schwartz
    Robert Jukic
    The Journal of Headache and Pain, 2019, 20
  • [27] DIHYDROERGOTAMINE - A REVIEW OF ITS USE IN THE TREATMENT OF MIGRAINE AND OTHER HEADACHES
    SCOTT, AK
    CLINICAL NEUROPHARMACOLOGY, 1992, 15 (04) : 289 - 296
  • [28] Real-world effectiveness of onabotulinumtoxinA treatment for the prevention of headaches in adults with chronic migraine in Australia: a retrospective study
    Stark, Catherine
    Stark, Richard
    Limberg, Nicole
    Rodrigues, Julian
    Cordato, Dennis
    Schwartz, Raymond
    Jukic, Robert
    JOURNAL OF HEADACHE AND PAIN, 2019, 20 (1):
  • [29] Correction to: OnabotulinumtoxinA: A Review in the Prevention of Chronic Migraine
    James E. Frampton
    Stephen Silberstein
    Drugs, 2018, 78 : 715 - 715
  • [30] OnabotulinumtoxinA for the prophylactic treatment of headaches in adult patients with chronic migraine: a safety evaluation
    Cheng, Fan
    Ahmed, Fayyaz
    EXPERT OPINION ON DRUG SAFETY, 2021, 20 (11) : 1275 - 1289
12345