A crucial requirement for Hedgehog signaling in small cell lung cancer

被引：0
|
作者：
Kwon-Sik Park
Luciano G Martelotto
Martin Peifer
Martin L Sos
Anthony N Karnezis
Moe R Mahjoub
Katie Bernard
Jamie F Conklin
Anette Szczepny
Jing Yuan
Ribo Guo
Beatrice Ospina
Jeanette Falzon
Samara Bennett
Tracey J Brown
Ana Markovic
Wendy L Devereux
Cory A Ocasio
James K Chen
Tim Stearns
Roman K Thomas
Marion Dorsch
Silvia Buonamici
D Neil Watkins
Craig D Peacock
Julien Sage
机构：
[1] Stanford University,Department of Pediatrics
[2] Stanford University,Department of Genetics
[3] Monash Institute of Medical Research,Department of Internal Medicine and Center of Integrated Oncology Köln
[4] Monash University,Bonn
[5] Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne,Department of Biology
[6] University of Cologne,Department of Biochemistry and Molecular Biology
[7] University of Cologne,Department of Chemical and Systems Biology
[8] University of California–San Francisco Department of Pathology,undefined
[9] Stanford University,undefined
[10] Novartis Institutes for Biomedical Research,undefined
[11] Monash University,undefined
[12] Sidney Kimmel Cancer Centre,undefined
[13] Johns Hopkins University School of Medicine,undefined
[14] Stanford University,undefined
[15] Laboratory of Translational Cancer Genomics,undefined
[16] Center of Integrated Oncology Köln-Bonn,undefined
[17] University of Cologne,undefined
来源：
Nature Medicine | 2011年 / 17卷
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中图分类号：
学科分类号：
摘要：
The authors find that cell-intrinsic activation of Hedgehog signaling without genetic alterations is a contributing feature to the progression and chemotherapy resistance of small-cell lung carcinoma, and that Hedgehog inhibition can prevent lung cancer growth and recurrence.
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页码：1504 / 1508
页数：4
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