A crucial requirement for Hedgehog signaling in small cell lung cancer

被引：0
|
作者：
Kwon-Sik Park
Luciano G Martelotto
Martin Peifer
Martin L Sos
Anthony N Karnezis
Moe R Mahjoub
Katie Bernard
Jamie F Conklin
Anette Szczepny
Jing Yuan
Ribo Guo
Beatrice Ospina
Jeanette Falzon
Samara Bennett
Tracey J Brown
Ana Markovic
Wendy L Devereux
Cory A Ocasio
James K Chen
Tim Stearns
Roman K Thomas
Marion Dorsch
Silvia Buonamici
D Neil Watkins
Craig D Peacock
Julien Sage
机构：
[1] Stanford University,Department of Pediatrics
[2] Stanford University,Department of Genetics
[3] Monash Institute of Medical Research,Department of Internal Medicine and Center of Integrated Oncology Köln
[4] Monash University,Bonn
[5] Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne,Department of Biology
[6] University of Cologne,Department of Biochemistry and Molecular Biology
[7] University of Cologne,Department of Chemical and Systems Biology
[8] University of California–San Francisco Department of Pathology,undefined
[9] Stanford University,undefined
[10] Novartis Institutes for Biomedical Research,undefined
[11] Monash University,undefined
[12] Sidney Kimmel Cancer Centre,undefined
[13] Johns Hopkins University School of Medicine,undefined
[14] Stanford University,undefined
[15] Laboratory of Translational Cancer Genomics,undefined
[16] Center of Integrated Oncology Köln-Bonn,undefined
[17] University of Cologne,undefined
来源：
Nature Medicine | 2011年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The authors find that cell-intrinsic activation of Hedgehog signaling without genetic alterations is a contributing feature to the progression and chemotherapy resistance of small-cell lung carcinoma, and that Hedgehog inhibition can prevent lung cancer growth and recurrence.
引用
收藏
页码：1504 / 1508
页数：4
相关论文
共 50 条
  • [11] HEDGEHOG PATHWAY ACTIVATION IS REQUIRED IN SMALL CELL LUNG CANCER
    不详
    CANCER DISCOVERY, 2011, 1 (06)
  • [12] Bromodomain and hedgehog pathway targets in small cell lung cancer
    Kaur, Gurmeet
    Reinhart, Russell A.
    Monks, Anne
    Evans, David
    Morris, Joel
    Polley, Eric
    Teicher, Beverly A.
    CANCER LETTERS, 2016, 371 (02) : 225 - 239
  • [13] In vitro hedgehog signaling pathway alterations after acquired-platinum resistance in small cell lung cancer
    Ranade, Aarati
    Weiss, Glen J.
    CANCER RESEARCH, 2010, 70
  • [14] Prognostic and predictive value of hedgehog (Hh) signaling in advanced non-small cell lung cancer (NSCLC).
    Berardi, Rossana
    Santinelli, Alfredo
    Onofri, Azzurra
    Caramanti, Miriam
    Savini, Agnese
    Chiorrini, Silvia
    Biscotti, Tommasina
    Ballatore, Zelmira
    De Lisa, Maria Grazia
    Mandolesi, Alessandra
    Biagetti, Simona
    Alfonsi, Simona
    Pompili, Cecilia
    Salati, Michele
    Brunelli, Alessandro
    Mazzanti, Paola
    Pierantoni, Chiara
    Sabbatini, Armando
    Bearzi, Italo
    Cascinu, Stefano
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [15] Hedgehog Inhibitor and Radiotherapy in Non-small Cell Lung Cancer
    Zeng, J.
    Aziz, K.
    Aftab, B.
    Armour, M.
    Chettair, S.
    Gajula, R.
    Salih, T.
    Rudin, C.
    Tran, P. T.
    Hales, R.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 81 (02): : S737 - S737
  • [16] Expression of hedgehog signaling molecules in lung cancer
    Huang, Shuhong
    Yang, Ling
    An, Yunhe
    Ma, Xiaoli
    Zhang, Chi
    Xie, Guorui
    Chen, Zhe-yu
    Xie, Jingwu
    Zhang, Hongwei
    ACTA HISTOCHEMICA, 2011, 113 (05) : 564 - 569
  • [17] Modulation of the Sonic Hedgehog Signaling Pathway in Non-small Cell Lung Cancer Targets Stem Cell-like Cancer Cells
    Csiki, I.
    Martyn, C.
    Freeman, M.
    Carbone, D.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 78 (03): : S112 - S113
  • [18] Activation of Hedgehog Signaling Pathway in Human Non-small Cell Lung Cancers
    Hong, Zhuan
    Bi, Aijing
    Chen, Dan
    Gao, Li
    Yin, Zhimin
    Luo, Lan
    PATHOLOGY & ONCOLOGY RESEARCH, 2014, 20 (04) : 917 - 922
  • [19] The Hedgehog signaling pathway in lung cancer: moving beyond inhibition of cell growth
    Rohatgi, Rajat
    JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) : S82 - S82
  • [20] Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development
    Lee, Hankyu
    Ko, Hyuk Wan
    BMB REPORTS, 2020, 53 (07) : 367 - 372
12345