γH2AX and cancer

被引：0
|
作者：
William M. Bonner
Christophe E. Redon
Jennifer S. Dickey
Asako J. Nakamura
Olga A. Sedelnikova
Stéphanie Solier
Yves Pommier
机构：
[1] William M. Bonner,
[2] Christophe E. Redon,undefined
[3] Jennifer S. Dickey,undefined
[4] Asako J. Nakamura,undefined
[5] Olga A. Sedelnikova,undefined
[6] Stéphanie Solier and Yves Pommier are at the Laboratory of Molecular Pharmacology,undefined
[7] Center for Cancer Research,undefined
[8] National Cancer Institute,undefined
[9] National Institutes of Health,undefined
[10] Bethesda,undefined
[11] Maryland 20892,undefined
[12] USA.,undefined
来源：
Nature Reviews Cancer | 2008年 / 8卷
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学科分类号：
摘要：
DNA double strand breaks (DSBs) may lead to cancer but, paradoxically, are also used to kill cancer cells. How might γH2AX — a surrogate marker of DSBs — be used to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs?
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页码：957 / 967
页数：10
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