γH2AX and cancer

被引：0
|
作者：
William M. Bonner
Christophe E. Redon
Jennifer S. Dickey
Asako J. Nakamura
Olga A. Sedelnikova
Stéphanie Solier
Yves Pommier
机构：
[1] William M. Bonner,
[2] Christophe E. Redon,undefined
[3] Jennifer S. Dickey,undefined
[4] Asako J. Nakamura,undefined
[5] Olga A. Sedelnikova,undefined
[6] Stéphanie Solier and Yves Pommier are at the Laboratory of Molecular Pharmacology,undefined
[7] Center for Cancer Research,undefined
[8] National Cancer Institute,undefined
[9] National Institutes of Health,undefined
[10] Bethesda,undefined
[11] Maryland 20892,undefined
[12] USA.,undefined
来源：
Nature Reviews Cancer | 2008年 / 8卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
DNA double strand breaks (DSBs) may lead to cancer but, paradoxically, are also used to kill cancer cells. How might γH2AX — a surrogate marker of DSBs — be used to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs?
引用
收藏
页码：957 / 967
页数：10
相关论文
共 50 条
  • [31] H2AX phosphorylation as a genotoxicity endpoint
    Watters, Gary Peter
    Smart, Daniel James
    Harvey, James Stephen
    Austin, Caroline Ann
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2009, 679 (1-2) : 50 - 58
  • [32] γ-H2AX: A sensitive Biodosimeter in radiotherapy?
    Zahnreich, S.
    Ebersberger, A.
    Mayer, A.
    Schmidberger, H.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2014, 190 : 34 - 35
  • [33] γ-H2AX与肿瘤治疗
    柴翠青
    孙青
    医学综述, 2009, 15 (03) : 350 - 352
  • [34] The role of γH2AX and H2AX in cervical carcinogenesis, invasion, and metastasis, and their relationship with the expression of E-cadherin
    Shang, Lina
    Li, Xiaoqin
    Song, Yihang
    Zhao, Jin
    Guo, Zhong
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2024, 46 (03) : 16 - 26
  • [35] Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus
    Siino, JS
    Nazarov, IB
    Svetlova, MP
    Solovjeva, LV
    Adamson, RH
    Zalenskaya, IA
    Yau, PM
    Bradbury, EM
    Tomilin, NV
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 297 (05) : 1318 - 1323
  • [36] Histone H2AX in DNA repair
    Lewandowska, H
    Szumiel, I
    NUKLEONIKA, 2002, 47 (04) : 127 - 131
  • [37] Is H2AX phosphorylation a biomarker for genotoxicity?
    Watters, Gary P.
    Harvey, James S.
    Austin, Caroline A.
    MUTAGENESIS, 2007, 22 (06) : 454 - 454
  • [38] Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response
    Wu, Ching-Yuan
    Kang, Hong-Yo
    Yang, Wei-Lei
    Wu, Juan
    Jeong, Yun Seong
    Wang, Jing
    Chan, Chia-Hsin
    Lee, Szu-Wei
    Zhang, Xian
    Lamothe, Betty
    Campos, Alejandro D.
    Darnay, Bryant G.
    Lin, Hui-Kuan
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (35) : 30806 - 30815
  • [39] γH2AX Applications for the evaluation of telomerase-based cancer therapy
    Nakamura, Asako J.
    Redon, Christophe E.
    Bonner, William M.
    CELL CYCLE, 2010, 9 (17) : 3385 - 3386
  • [40] Utility of anti-phosphorylated H2AX antibody (gamma]-H2AX) in diagnosing metastatic renal cell carcinoma
    Wasco, M. J.
    Pu, R. T.
    MODERN PATHOLOGY, 2007, 20 : 183A - 183A
12345