Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity

被引：0

作者：

M. P. Davydova

I. V. Sorokina

T. G. Tolstikova

V. I. Mamatyuk

D. S. Fadeev

S. F. Vasilevsky

机构：

[1] Russian Academy of Sciences,Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch

[2] Russian Academy of Sciences,Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch

[3] Novosibirsk State University,undefined

来源：

Russian Journal of Bioorganic Chemistry | 2015年 / 41卷

关键词：

combretastatin A-4; α-acetylenic ketones; β-vinylamines; anti-inflammatory activity; vasoactive properties;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the β-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.

引用

页码：70 / 76

页数：6

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