Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity

被引：0
|
作者：
M. P. Davydova
I. V. Sorokina
T. G. Tolstikova
V. I. Mamatyuk
D. S. Fadeev
S. F. Vasilevsky
机构：
[1] Russian Academy of Sciences,Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch
[2] Russian Academy of Sciences,Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
[3] Novosibirsk State University,undefined
来源：
Russian Journal of Bioorganic Chemistry | 2015年 / 41卷
关键词：
combretastatin A-4; α-acetylenic ketones; β-vinylamines; anti-inflammatory activity; vasoactive properties;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new approach to the synthesis of natural combretastatin A-4 analogues based on the interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) was proposed. Previously unknown analogues of combretastatin A-4 containing the β-aminovinylcarbonyl bridges were synthesized. Anti-inflammatory activity of the obtained compounds was studied on models of exudative inflammation caused by histamine or concanavalin A.
引用
收藏
页码：70 / 76
页数：6
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