Genome-wide profiling of in vivo RNA structure at single-nucleotide resolution using structure-seq

被引:0
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作者
Yiliang Ding
Chun Kit Kwok
Yin Tang
Philip C Bevilacqua
Sarah M Assmann
机构
[1] Pennsylvania State University,Department of Biology
[2] University Park,Department of Chemistry
[3] Pennsylvania State University,undefined
[4] University Park,undefined
[5] Center for RNA Molecular Biology,undefined
[6] Pennsylvania State University,undefined
[7] University Park,undefined
[8] Bioinformatics and Genomics Graduate Program,undefined
[9] Pennsylvania State University,undefined
[10] University Park,undefined
[11] Plant Biology Graduate Program,undefined
[12] Pennsylvania State University,undefined
[13] University Park,undefined
[14] Present address: Department of Cell and Developmental Biology,undefined
[15] John Innes Centre,undefined
[16] Norwich Research Park,undefined
[17] Norwich,undefined
[18] UK.,undefined
[19] Present address: Department of Chemistry,undefined
[20] University of Cambridge,undefined
[21] Lensfield Road,undefined
[22] Cambridge,undefined
[23] UK.,undefined
来源
Nature Protocols | 2015年 / 10卷
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摘要
Structure-seq applies chemically based RNA structure probing on a genome-wide scale, allowing the in vivo structures of thousands of distinct transcripts to be discerned, and the meta-properties of RNA structure–function relationships to be unveiled.
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页码:1050 / 1066
页数:16
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