Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

被引：0

作者：

Miguel López

Luis Varela

María J Vázquez

Sergio Rodríguez-Cuenca

Carmen R González

Vidya R Velagapudi

Donald A Morgan

Erik Schoenmakers

Khristofor Agassandian

Ricardo Lage

Pablo Blanco Martínez de Morentin

Sulay Tovar

Rubén Nogueiras

David Carling

Christopher Lelliott

Rosalía Gallego

Matej Orešič

Krishna Chatterjee

Asish K Saha

Kamal Rahmouni

Carlos Diéguez

Antonio Vidal-Puig

机构：

[1] School of Medicine,Department of Physiology

[2] University of Santiago de Compostela-Instituto de Investigación Sanitaria,Department of Internal Medicine

[3] Santiago de Compostela (A Coruña),Department of Anatomy and Cell Biology

[4] Spain.,Department of Biosciences

[5] Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBERobn) (A Coruña),Department of Morphological Sciences

[6] Institute of Metabolic Science,undefined

[7] Metabolic Research Laboratories,undefined

[8] Addenbrooke's Hospital,undefined

[9] University of Cambridge,undefined

[10] Technical Research Centre of Finland (VTT),undefined

[11] University of Iowa Carver College of Medicine,undefined

[12] University of Iowa Carver College of Medicine,undefined

[13] Cellular Stress Group,undefined

[14] Medical Research Council Clinical Sciences Centre,undefined

[15] Hammersmith Hospital,undefined

[16] Imperial College,undefined

[17] AstraZeneca,undefined

[18] Research and Development,undefined

[19] School of Medicine,undefined

[20] University of Santiago de Compostela (A Coruña),undefined

[21] Spain.,undefined

[22] Diabetes Research Unit,undefined

[23] Boston Medical Center,undefined

来源：

Nature Medicine | 2010年 / 16卷

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中图分类号：

学科分类号：

摘要：

Thyroid hormones are well known to regulate whole-body energy metabolism, which was believed to occur as a direct effect on individual cells in the periphery. But Antonio Vidal-Puig and his colleagues now show that these thyroid hormone effects on energy regulation are actually indirect, as they regulate AMPK activity in the hypothalamus and thus central signaling to brown adipose tissue in the periphery.

引用

页码：1001 / 1008

页数：7

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