Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

被引：0

作者：

Miguel López

Luis Varela

María J Vázquez

Sergio Rodríguez-Cuenca

Carmen R González

Vidya R Velagapudi

Donald A Morgan

Erik Schoenmakers

Khristofor Agassandian

Ricardo Lage

Pablo Blanco Martínez de Morentin

Sulay Tovar

Rubén Nogueiras

David Carling

Christopher Lelliott

Rosalía Gallego

Matej Orešič

Krishna Chatterjee

Asish K Saha

Kamal Rahmouni

Carlos Diéguez

Antonio Vidal-Puig

机构：

[1] School of Medicine,Department of Physiology

[2] University of Santiago de Compostela-Instituto de Investigación Sanitaria,Department of Internal Medicine

[3] Santiago de Compostela (A Coruña),Department of Anatomy and Cell Biology

[4] Spain.,Department of Biosciences

[5] Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBERobn) (A Coruña),Department of Morphological Sciences

[6] Institute of Metabolic Science,undefined

[7] Metabolic Research Laboratories,undefined

[8] Addenbrooke's Hospital,undefined

[9] University of Cambridge,undefined

[10] Technical Research Centre of Finland (VTT),undefined

[11] University of Iowa Carver College of Medicine,undefined

[12] University of Iowa Carver College of Medicine,undefined

[13] Cellular Stress Group,undefined

[14] Medical Research Council Clinical Sciences Centre,undefined

[15] Hammersmith Hospital,undefined

[16] Imperial College,undefined

[17] AstraZeneca,undefined

[18] Research and Development,undefined

[19] School of Medicine,undefined

[20] University of Santiago de Compostela (A Coruña),undefined

[21] Spain.,undefined

[22] Diabetes Research Unit,undefined

[23] Boston Medical Center,undefined

来源：

Nature Medicine | 2010年 / 16卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Thyroid hormones are well known to regulate whole-body energy metabolism, which was believed to occur as a direct effect on individual cells in the periphery. But Antonio Vidal-Puig and his colleagues now show that these thyroid hormone effects on energy regulation are actually indirect, as they regulate AMPK activity in the hypothalamus and thus central signaling to brown adipose tissue in the periphery.

引用

页码：1001 / 1008

页数：7

共 50 条

[21] HYPOTHALAMIC REGULATION OF ENERGY-BALANCE AND FEEDING BEHAVIOR
PANKSEPP, J
FEDERATION PROCEEDINGS, 1974, 33 (05) : 1150 - 1165
[22] Developmental Programming of Energy Balance and Its Hypothalamic Regulation
Remmers, Floor
Delemarre-van de Waal, Henriette A.
ENDOCRINE REVIEWS, 2011, 32 (02) : 272 - 311
[23] Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance
Lage, Ricardo
Ferno, Johan
Nogueiras, Ruben
Dieguez, Carlos
Lopez, Miguel
BIOCHEMICAL JOURNAL, 2016, 473 : 4063 - 4082
[24] Expanding neurotransmitters in the hypothalamic neurocircuitry for energy balance regulation
Yuanzhong Xu
Qingchun Tong
Protein & Cell, 2011, 2 (10) : 800 - 813
[25] Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
Ke, Rong
Xu, Qicao
Li, Cong
Luo, Lingyu
Huang, Deqiang
CELL BIOLOGY INTERNATIONAL, 2018, 42 (04) : 384 - 392
[26] Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
Martinez-Sanchez, Noelia
Seoane-Collazo, Patricia
Contreras, Cristina
Varela, Luis
Villarroya, Joan
Rial-Pensado, Eva
Buque, Xabier
Aurrekoetxea, Igor
Delgado, Teresa C.
Vazquez-Martinez, Rafael
Gonzalez-Garcia, Ismael
Roa, Juan
Whittle, Andrew J.
Gomez-Santos, Beatriz
Velagapudi, Vidya
Loraine Tung, Y. C.
Morgan, Donald A.
Voshol, Peter J.
Martinez de Morentin, Pablo B.
Lopez-Gonzalez, Tania
Linares-Pose, Laura
Gonzalez, Francisco
Chatterjee, Krishna
Sobrino, Tomas
Medina-Gomez, Gema
Davis, Roger J.
Casals, Nuria
Oresic, Matej
Coll, Anthony P.
Vidal-Puig, Antonio
Mittag, Jens
Tena-Sempere, Manuel
Malagon, Maria M.
Dieguez, Carlos
Martinez-Chantar, Maria Luz
Aspichueta, Patricia
Rahmouni, Kamal
Nogueiras, Ruben
Sabio, Guadalupe
Villarroya, Francesc
Lopez, Miguel
CELL METABOLISM, 2017, 26 (01) : 212 - +
[27] Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
Ferreira, Vitor
Folgueira, Cintia
Guillen, Maria
Zubiaur, Pablo
Navares, Marcos
Sarsenbayeva, Assel
Lopez-Larrubia, Pilar
Eriksson, Jan W.
Pereira, Maria J.
Abad-Santos, Francisco
Sabio, Guadalupe
Rada, Patricia
Valverde, Angela M.
METABOLISM-CLINICAL AND EXPERIMENTAL, 2022, 137
[28] Modulation of hypothalamic AMPK phosphorylation by Olanzapine controls energy balance and body weight
Ferreira, V.
Folgueira, C.
Guillen, M.
Zubiaur, P.
Grajales, D.
Sarsenbayeva, A.
Lopez Larrubia, P.
Eriksson, J. W.
Pereira, M. J.
Abad-Santos, F.
Sabio, G.
Rada, P.
Valverde, A. M.
DIABETOLOGIA, 2022, 65 (SUPPL 1) : S112 - S112
[29] SYMPOSIUM ON REGULATION OF ENERGY-BALANCE - REGULATION OF ENERGY-BALANCE - STUDIES ON GENETIC, HYPOTHALAMIC AND DIETARY OBESITY
BRAY, GA
PROCEEDINGS OF THE NUTRITION SOCIETY, 1982, 41 (02) : 95 - 108
[30] Regulation of plasma fatty acid metabolism
Saleh, J
Sniderman, AD
Cianflone, K
CLINICA CHIMICA ACTA, 1999, 286 (1-2) : 163 - 180

← 1 2 3 4 5 →