Synthesis of Some Novel 3-Spiro Monocyclic β-Lactams and Their Antibacterial and Antifungal Investigations

被引：0
|
作者：
Aliasghar Jarrahpour
Shadab Rezaei
Véronique Sinou
Christine Latour
Jean Michel Brunel
机构：
[1] Shiraz University,Department of Chemistry, College of Sciences
[2] Aix-Marseille Université,UMR
[3] Centre de Recherche en Cancérologie de Marseille (CRCM),MD3 Relation hôte
[4] CNRS,parasites, Physiopathologie and Pharmacologie, Faculté de Pharmacie
[5] UMR7258,UM 105, Inserm, U1068, Faculté de pharmacie
[6] Institut Paoli Calmettes,undefined
[7] Aix-Marseille Université,undefined
来源：
Iranian Journal of Science and Technology, Transactions A: Science | 2017年 / 41卷
关键词：
Spiro β-lactams; Staudinger reaction; 9H-Xanthene-9-carbonyl chloride; [2+2] Cycloaddition; Antimalarial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel series of new 3-spiro monocyclic β-lactams 3a–i have been synthesized in high chemical yields from 9H-xanthene-9-carbonyl chloride 2 as ketene source in the [2+2] cycloaddition (Staudinger reaction) with different aromatic imines. These newly synthesized β-lactams were fully characterized and evaluated for their antimalarial activities against Plasmodium falciparum K14-resistant strain with moderate to excellent EC50 values varying from 8 up to 50 µM.
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页码：337 / 342
页数：5
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