Synthesis of Some Novel 3-Spiro Monocyclic β-Lactams and Their Antibacterial and Antifungal Investigations

被引：0

作者：

Aliasghar Jarrahpour

Shadab Rezaei

Véronique Sinou

Christine Latour

Jean Michel Brunel

机构：

[1] Shiraz University,Department of Chemistry, College of Sciences

[2] Aix-Marseille Université,UMR

[3] Centre de Recherche en Cancérologie de Marseille (CRCM),MD3 Relation hôte

[4] CNRS,parasites, Physiopathologie and Pharmacologie, Faculté de Pharmacie

[5] UMR7258,UM 105, Inserm, U1068, Faculté de pharmacie

[6] Institut Paoli Calmettes,undefined

[7] Aix-Marseille Université,undefined

来源：

Iranian Journal of Science and Technology, Transactions A: Science | 2017年 / 41卷

关键词：

Spiro β-lactams; Staudinger reaction; 9H-Xanthene-9-carbonyl chloride; [2+2] Cycloaddition; Antimalarial activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A novel series of new 3-spiro monocyclic β-lactams 3a–i have been synthesized in high chemical yields from 9H-xanthene-9-carbonyl chloride 2 as ketene source in the [2+2] cycloaddition (Staudinger reaction) with different aromatic imines. These newly synthesized β-lactams were fully characterized and evaluated for their antimalarial activities against Plasmodium falciparum K14-resistant strain with moderate to excellent EC50 values varying from 8 up to 50 µM.

引用

页码：337 / 342

页数：5

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