Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction

被引：0
|
作者：
Insun Park
Ashwini M. Londhe
Ji Woong Lim
Beoung-Geon Park
Seo Yun Jung
Jae Yeol Lee
Sang Min Lim
Kyoung Tai No
Jiyoun Lee
Ae Nim Pae
机构：
[1] Korea Institute of Science and Technology (KIST),Convergence Research Center for Diagnosis, Treatment and Care System of Dementia
[2] Yonsei University,Department of Biotechnology
[3] KyungHee University,Department of Converging Science and Technology
[4] Korea Institute of Science and Technology (KIST),Center for Neuro
[5] Korea University,Medicine
[6] Korea University of Science and Technology,School of Life Sciences and Biotechnology
[7] Sungshin University,Division of Bio
来源：
Journal of Computer-Aided Molecular Design | 2017年 / 31卷
关键词：
Cyclophilin D (CypD); Small molecule inhibitors; Mitochondrial permeability transition pore (mPTP); Alzheimer’s disease (AD); Energy-based pharmacophore; Molecular docking; Virtual screening;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：929 / 941
页数：12
相关论文
共 50 条
  • [41] Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite
    Nienaber, VL
    Davidson, D
    Edalji, R
    Giranda, VL
    Klinghofer, V
    Henkin, J
    Magdalinos, P
    Mantei, R
    Merrick, S
    Severin, JM
    Smith, RA
    Stewart, K
    Walter, K
    Wang, JY
    Wendt, M
    Weitzberg, M
    Zhao, XM
    Rockway, T
    STRUCTURE, 2000, 8 (05) : 553 - 563
  • [42] C105SR, a novel non-peptidic small-molecule cyclophilin inhibitor with potent mitoprotective and hepatoprotective properties in the context of hepatic ischemia/reperfusion injury
    Kheyar, Amel
    Ahnou, Nazim
    Ahmed-Belkacem, Hakim
    Ghaleh, Bijan
    Guichou, Jean-Francois
    Morin, Didier
    Pawlotsky, Jean-Michel
    Teixeira-Clerc, Fatima
    JOURNAL OF HEPATOLOGY, 2023, 78 : S456 - S456
  • [43] Discovery of non-peptidic P2-P3 butanediamide renin inhibitors with high oral efficacy
    Simoneau, B
    Lavallée, P
    Anderson, PC
    Bailey, M
    Bantle, G
    Berthiaume, S
    Chabot, C
    Fazal, G
    Halmos, T
    Ogilvie, WW
    Poupart, MA
    Thavonekham, B
    Xin, ZL
    Thibeault, D
    Bolger, G
    Panzenbeck, M
    Winquist, R
    Jung, GL
    BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (03) : 489 - 508
  • [44] Development of Small Molecule Inhibitors of Cyclophilin D for Treatment of Severe Acute Pancreatitis
    Awais, M.
    Javed, M. A.
    Wen, L.
    Gibson, R.
    Shore, E.
    Kershaw, N.
    Criddle, D. N.
    Tepikin, A.
    Berry, N.
    O'Neill, P.
    Lian, L-Y
    Park, B. K.
    Sutton, R.
    PANCREAS, 2013, 42 (08) : 1338 - 1338
  • [45] QSAR study on 5,6-dihydropyran-7-ones for the discovery of potent non-peptidic inhibitors of HIV protease
    Srivastava, A. K.
    Varma, A.
    OXIDATION COMMUNICATIONS, 2006, 29 (03): : 545 - 554
  • [46] The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure
    Zhao, JH
    Wang, MJ
    Chen, J
    Luo, AP
    Wang, XQ
    Wu, M
    Yin, DL
    Liu, ZH
    CANCER LETTERS, 2002, 183 (01) : 69 - 77
  • [47] Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy
    Seneci, Pierfausto
    Bianchi, Aldo
    Battaglia, Cristina
    Belvisi, Laura
    Bolognesi, Martino
    Caprini, Andrea
    Cossu, Federica
    de Franco, Elena
    de Matteo, Marilenia
    Delia, Domenico
    Drago, Carmelo
    Khaled, Amira
    Lecis, Daniele
    Manzoni, Leonardo
    Marizzoni, Moira
    Mastrangelo, Eloise
    Milani, Mario
    Motto, Ilaria
    Moroni, Elisabetta
    Potenza, Donatella
    Rizzo, Vincenzo
    Servida, Federica
    Turlizzi, Elisa
    Varrone, Maurizio
    Vasile, Francesca
    Scolastico, Carlo
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (16) : 5834 - 5856
  • [48] Fragment screening and its application to drug design: The discovery of low molecular weight, non-peptidic, nanomolar inhibitors of beta-secretase
    Edwards, Philip D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 531 - 531
  • [49] Recent advances in the discovery of non-peptidic direct renin inhibitors as anti hypertensives: new patent applications in years 2000-2008
    Yokokawa, Fumiaki
    Maibaum, Juergen
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2008, 18 (06) : 581 - 602
  • [50] Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases
    Haleckova, Annamaria
    Benek, Ondrej
    Zemanova, Lucie
    Dolezal, Rafael
    Musilek, Kamil
    MEDICINAL RESEARCH REVIEWS, 2022, 42 (05) : 1822 - 1855
12345