Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction

被引:0
|
作者
Insun Park
Ashwini M. Londhe
Ji Woong Lim
Beoung-Geon Park
Seo Yun Jung
Jae Yeol Lee
Sang Min Lim
Kyoung Tai No
Jiyoun Lee
Ae Nim Pae
机构
[1] Korea Institute of Science and Technology (KIST),Convergence Research Center for Diagnosis, Treatment and Care System of Dementia
[2] Yonsei University,Department of Biotechnology
[3] KyungHee University,Department of Converging Science and Technology
[4] Korea Institute of Science and Technology (KIST),Center for Neuro
[5] Korea University,Medicine
[6] Korea University of Science and Technology,School of Life Sciences and Biotechnology
[7] Sungshin University,Division of Bio
关键词
Cyclophilin D (CypD); Small molecule inhibitors; Mitochondrial permeability transition pore (mPTP); Alzheimer’s disease (AD); Energy-based pharmacophore; Molecular docking; Virtual screening;
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学科分类号
摘要
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页码:929 / 941
页数:12
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