BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

被引：0
|
作者：
Erica Korb
Margo Herre
Ilana Zucker-Scharff
Robert B Darnell
C David Allis
机构：
[1] Laboratory of Chromatin Biology and Epigenetics,
[2] The Rockefeller University,undefined
[3] Laboratory of Molecular Neuro-oncology,undefined
[4] The Rockefeller University,undefined
来源：
Nature Neuroscience | 2015年 / 18卷
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学科分类号：
摘要：
Memory formation requires gene transcription, but the link between synaptic activity and transcription is not fully understood. Brd4 regulates transcription in other cell types and Brd4 family inhibitors are in clinical trials for cancer. The authors show that Brd4 is important for activity-dependent gene transcription in neurons and memory consolidation.
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页码：1464 / 1473
页数：9
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