BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

被引：0
|
作者：
Erica Korb
Margo Herre
Ilana Zucker-Scharff
Robert B Darnell
C David Allis
机构：
[1] Laboratory of Chromatin Biology and Epigenetics,
[2] The Rockefeller University,undefined
[3] Laboratory of Molecular Neuro-oncology,undefined
[4] The Rockefeller University,undefined
来源：
Nature Neuroscience | 2015年 / 18卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Memory formation requires gene transcription, but the link between synaptic activity and transcription is not fully understood. Brd4 regulates transcription in other cell types and Brd4 family inhibitors are in clinical trials for cancer. The authors show that Brd4 is important for activity-dependent gene transcription in neurons and memory consolidation.
引用
收藏
页码：1464 / 1473
页数：9
相关论文
共 50 条
  • [31] The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
    Feng, Mei
    Xu, Hao
    Zhou, Wenyuan
    Pan, Yisheng
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023, 42 (01)
  • [32] Therapeutic targeting of BET protein BRD4 delays murine lupus
    Wei, Shitong
    Sun, Yonghua
    Sha, Hongyu
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 29 (02) : 314 - 319
  • [33] Modulation of Virulence-Associated Traits in Aspergillus fumigatus by BET Inhibitor JQ1
    Orekhova, Anastasia
    De Angelis, Marta
    Cacciotti, Andrea
    Reverberi, Massimo
    Rotili, Dante
    Giorgi, Alessandra
    Protto, Virginia
    Bonincontro, Graziana
    Fiorentino, Francesco
    Zgoda, Victor
    Mai, Antonello
    Palamara, Anna Teresa
    Simonetti, Giovanna
    MICROORGANISMS, 2022, 10 (11)
  • [34] BET bromodomain inhibitor JQ1 modulates microRNA expression in thyroid cancer cells
    Mio, Catia
    Conzatti, Ketty
    Baldan, Federica
    Allegri, Lorenzo
    Sponziello, Marialuisa
    Rosignolo, Francesca
    Russo, Diego
    Filetti, Sebastiano
    Damante, Giusepe
    ONCOLOGY REPORTS, 2018, 39 (02) : 582 - 588
  • [35] The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells
    Garcia, Patrick L.
    Miller, Aubrey L.
    Zeng, Ling
    van Waardenburg, Robert C. A. M.
    Yang, Eddy S.
    Yoon, Karina J.
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [36] The BET-bromodomain inhibitor JQ1 mitigates vemurafenib drug resistance in melanoma
    Zhao, Bei
    Cheng, Xiankui
    Zhou, Xiyuan
    MELANOMA RESEARCH, 2018, 28 (06) : 521 - 526
  • [37] The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma
    Bid, Hemant K.
    Phelps, Doris A.
    Xaio, Linlin
    Guttridge, Denis C.
    Lin, Jiayuh
    London, Cheryl
    Baker, Laurence H.
    Mo, Xiaokui
    Houghton, Peter J.
    MOLECULAR CANCER THERAPEUTICS, 2016, 15 (05) : 1018 - 1028
  • [38] Affinity Map of Bromodomain Protein 4 ( BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1
    Jung, Marie
    Philpott, Martin
    Mueller, Susanne
    Schulze, Jessica
    Badock, Volker
    Eberspaecher, Uwe
    Moosmayer, Dieter
    Bader, Benjamin
    Schmees, Norbert
    Fernandez-Montalvan, Amaury
    Haendler, Bernard
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (13) : 9304 - 9319
  • [39] The BRD4 Inhibitor I-BET-762 Reduces HO-1 Expression in Macrophages and the Pancreas of Mice
    Leal, Ana S.
    Liby, Karen T.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (18)
  • [40] BET Protein Inhibitor JQ1 Modulates Mitochondrial Dysfunction and Oxidative Stress Induced by Chronic Kidney Disease
    Rayego-Mateos, Sandra
    Basantes, Pamela
    Morgado-Pascual, Jose Luis
    Prieto, Beatriz Brazal
    Suarez-Alvarez, Beatriz
    Ortiz, Alberto
    Lopez-Larrea, Carlos
    Ruiz-Ortega, Marta
    ANTIOXIDANTS, 2023, 12 (05)
12345