The genomic landscape of nasopharyngeal carcinoma

被引：0

作者：

De-Chen Lin

Xuan Meng

Masaharu Hazawa

Yasunobu Nagata

Ana Maria Varela

Liang Xu

Yusuke Sato

Li-Zhen Liu

Ling-Wen Ding

Arjun Sharma

Boon Cher Goh

Soo Chin Lee

Bengt Fredrik Petersson

Feng Gang Yu

Paul Macary

Min Zin Oo

Chan Soh Ha

Henry Yang

Seishi Ogawa

Kwok Seng Loh

H Phillip Koeffler

机构：

[1] Cancer Science Institute of Singapore,Division of Hematology/Oncology

[2] National University of Singapore,Department of Medicine

[3] Cedars-Sinai Medical Center,Department of Pathology and Tumor Biology

[4] University of California,Department of Haematology

[5] Los Angeles School of Medicine,Oncology

[6] School of Medicine,Department of Pathology

[7] National University of Singapore,Department of Otolaryngology

[8] Cancer Genomics Project,Department of Immunology

[9] Graduate School of Medicine,Department of Microbiology

[10] The University of Tokyo,undefined

[11] Graduate School of Medicine,undefined

[12] Kyoto University,undefined

[13] National University Cancer Institute,undefined

[14] National University Health System,undefined

[15] National University Hospital Singapore,undefined

[16] National University of Singapore,undefined

[17] National University of Singapore,undefined

[18] National University Cancer Institute,undefined

[19] National University Hospital Singapore,undefined

来源：

Nature Genetics | 2014年 / 46卷

关键词：

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中图分类号：

学科分类号：

摘要：

De-Chen Lin and colleagues report whole-exome sequencing, targeted sequencing and SNP array analysis of 128 cases of nasopharyngeal carcinoma (NPC), a tumor type connected to Epstein-Barr virus infection. Their results identify a distinct mutational signature with nine significantly mutated genes and mutations enriched in cellular processes, including chromatin modification and autophagy.

引用

页码：866 / 871

页数：5

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