The genomic landscape of nasopharyngeal carcinoma

被引：0
|
作者：
De-Chen Lin
Xuan Meng
Masaharu Hazawa
Yasunobu Nagata
Ana Maria Varela
Liang Xu
Yusuke Sato
Li-Zhen Liu
Ling-Wen Ding
Arjun Sharma
Boon Cher Goh
Soo Chin Lee
Bengt Fredrik Petersson
Feng Gang Yu
Paul Macary
Min Zin Oo
Chan Soh Ha
Henry Yang
Seishi Ogawa
Kwok Seng Loh
H Phillip Koeffler
机构：
[1] Cancer Science Institute of Singapore,Division of Hematology/Oncology
[2] National University of Singapore,Department of Medicine
[3] Cedars-Sinai Medical Center,Department of Pathology and Tumor Biology
[4] University of California,Department of Haematology
[5] Los Angeles School of Medicine,Oncology
[6] School of Medicine,Department of Pathology
[7] National University of Singapore,Department of Otolaryngology
[8] Cancer Genomics Project,Department of Immunology
[9] Graduate School of Medicine,Department of Microbiology
[10] The University of Tokyo,undefined
[11] Graduate School of Medicine,undefined
[12] Kyoto University,undefined
[13] National University Cancer Institute,undefined
[14] National University Health System,undefined
[15] National University Hospital Singapore,undefined
[16] National University of Singapore,undefined
[17] National University of Singapore,undefined
[18] National University Cancer Institute,undefined
[19] National University Hospital Singapore,undefined
来源：
Nature Genetics | 2014年 / 46卷
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摘要：
De-Chen Lin and colleagues report whole-exome sequencing, targeted sequencing and SNP array analysis of 128 cases of nasopharyngeal carcinoma (NPC), a tumor type connected to Epstein-Barr virus infection. Their results identify a distinct mutational signature with nine significantly mutated genes and mutations enriched in cellular processes, including chromatin modification and autophagy.
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页码：866 / 871
页数：5
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