Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin

被引:0
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作者
Celme Vieira
Steffen Fetzer
Susanne K. Sauer
Stefano Evangelista
Beate Averbeck
Michaela Kress
Peter W. Reeh
Rocco Cirillo
Annalisa Lippi
Carlo A. Maggi
Stefano Manzini
机构
[1] Faculdade de Medicine de Riberào Preto,
[2] U.S.P.,undefined
[3] Brazil,undefined
[4] Department of Pharmacology,undefined
[5] Menarini Ricerche spa,undefined
[6] Pomezia (Rome),undefined
[7] Italy,undefined
[8] Preclinical Development,undefined
[9] Menarini Ricerche spa,undefined
[10] Via Sette Santi 1,undefined
[11] 50131 Firenze,undefined
[12] Italy,undefined
[13] Institute of Physiology and Experimental Pathophysiology,undefined
[14] University of Erlangen/Nürnberg,undefined
[15] Germany,undefined
关键词
Calcitonin gene-related peptide Capsaicin Carrageenan Castor oil Inflammation Ricinoleic acid Substance P;
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学科分类号
摘要
We have investigated the pro- and anti-inflammatory effects of ricinoleic acid (RA), the main active principle of castor oil, in an experimental model of blepharitis induced by intradermal injection of carrageenan in the guinea-pig eyelid and its possible capsaicin-like mode of action on acutely dissociated rat dorsal root ganglia (DRG) neurons in vitro.
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页码:87 / 95
页数:8
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