Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones

被引：0
|
作者：
G. Turchi
H.R. Glatt
A. Seidel
A. Puliti
I. Sbrana
机构：
[1] J.R.C. Environmental Institute,European Centre for the Validation of Alternative Methods (ECVAM)
[2] German Institute of Human Nutrition,Institute of Toxicology
[3] University of Mainz,undefined
[4] Dipartimento di Scienze dell‘Ambiente e del Territorio dell’Universita',undefined
来源：
Cell Biology and Toxicology | 1997年 / 13卷
关键词：
cultured liver cells; chromosomal aberrations; structure-activity relationship;
D O I：
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摘要：
Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect. However, all four compounds enhanced the frequency of c-mitoses.
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页码：155 / 165
页数：10
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