Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones

被引：2
|
作者：
Turchi, G
Glatt, HR
Seidel, A
Puliti, A
Sbrana, I
机构：
[1] GERMAN INST HUMAN NUTR, POTSDAM, GERMANY
[2] UNIV MAINZ, INST TOXICOL, D-6500 MAINZ, GERMANY
[3] UNIV PISA, DIPARTIMENTO SCI AMBIENTE & TERR, I-56100 PISA, ITALY
来源：
CELL BIOLOGY AND TOXICOLOGY | 1997年 / 13卷 / 03期
关键词：
cultured liver cells; chromosomal aberrations; structure-activity relationship;
D O I：
10.1023/A:1007302111081
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect. However, all four compounds enhanced the frequency of c-mitoses.
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页码：155 / 165
页数：11
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