Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones

被引：2
|
作者：
Turchi, G
Glatt, HR
Seidel, A
Puliti, A
Sbrana, I
机构：
[1] GERMAN INST HUMAN NUTR, POTSDAM, GERMANY
[2] UNIV MAINZ, INST TOXICOL, D-6500 MAINZ, GERMANY
[3] UNIV PISA, DIPARTIMENTO SCI AMBIENTE & TERR, I-56100 PISA, ITALY
来源：
CELL BIOLOGY AND TOXICOLOGY | 1997年 / 13卷 / 03期
关键词：
cultured liver cells; chromosomal aberrations; structure-activity relationship;
D O I：
10.1023/A:1007302111081
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect. However, all four compounds enhanced the frequency of c-mitoses.
引用
收藏
页码：155 / 165
页数：11
相关论文
共 50 条
  • [21] SIGNIFICANT DIFFERENCES IN THE STRUCTURAL BASIS OF THE INDUCTION OF SISTER CHROMATID EXCHANGES AND CHROMOSOMAL-ABERRATIONS IN CHINESE-HAMSTER OVARY CELLS
    ROSENKRANZ, HS
    ENNEVER, FK
    DIMAYUGA, M
    KLOPMAN, G
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1990, 16 (03) : 149 - 177
  • [22] INDUCTION OF CHROMOSOMAL-ABERRATIONS WITH THE RESTRICTION ENDONUCLEASE ALUI IN CHINESE-HAMSTER OVARY CELLS - COMPARISON OF DIFFERENT TREATMENT METHODS
    JOHANNES, C
    OBE, G
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1991, 59 (06) : 1379 - 1393
  • [23] THE SYNERGISTIC EFFECTS OF SV40 AND BUDR ON INDUCTION OF GENE-MUTATIONS AND CHROMOSOMAL-ABERRATIONS IN CHINESE-HAMSTER CELLS
    VARSHAVER, NB
    MARSHAK, MI
    GORBUNOVA, LV
    LUKASH, LL
    SHAPIRO, NI
    MUTATION RESEARCH, 1980, 70 (03): : 351 - 364
  • [24] Influence of sodium butyrate on the induction of radiation-induced chromosomal aberrations and sister chromatid exchanges in Chinese hamster ovary (CHO) cells
    Johannes, C
    Schunck, C
    Hüsing, J
    Obe, G
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1999, 429 (01) : 141 - 146
  • [25] TEST FOR INDUCTION OF CHROMOSOMAL-ABERRATIONS IN CHINESE-HAMSTER OVARY CELLS (INVITRO) BY 2-(2',4'-DIAMINOPHENOXY)ETHANOL
    DARROUDI, F
    VANKESTERENVANLEEUWEN, AC
    NATARAJAN, AT
    MUTATION RESEARCH, 1982, 102 (04): : 351 - 355
  • [26] Structure-activity relationship and role of oxygen in the potential antitumour activity of fluoroquinolones in human epithelial cancer cells
    Perucca, Paola
    Savio, Monica
    Cazzalini, Ornella
    Mocchi, Roberto
    Maccario, Cristina
    Sommatis, Sabrina
    Ferraro, Daniela
    Pizzala, Roberto
    Pretali, Luca
    Fasani, Elisa
    Albini, Angelo
    Stivala, Lucia Anna
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2014, 140 : 57 - 68
  • [27] INDUCTION OF CHROMOSOMAL-ABERRATIONS IN ACTIVE OXYGEN-GENERATING SYSTEMS .1. EFFECTS OF PARAQUAT IN CHINESE-HAMSTER CELLS IN CULTURE
    SOFUNI, T
    ISHIDATE, M
    MUTATION RESEARCH, 1988, 197 (01): : 127 - 132
  • [28] SPINDLE FIDELITY AND THE INDUCTION OF STRUCTURAL AND NUMERICAL CHROMOSOME-ABERRATIONS IN PRIMARY CHINESE-HAMSTER CELLS AFTER EXPOSURE TO CIGARETTE-SMOKE CONDENSATE
    LAFI, A
    PARRY, JM
    MUTATION RESEARCH, 1988, 203 (03): : 223 - 223
  • [29] INDUCTION OF CHROMOSOMAL-ABERRATIONS IN CHINESE-HAMSTER OVARY CELLS BY THE RESTRICTION ENDONUCLEASE DRA-I - DOSE EFFECT RELATIONSHIPS AND EFFECT OF SUBSTITUTION OF CHROMOSOMAL DNA WITH BROMODEOXYURIDINE
    OBE, G
    JOHANNES, C
    VASUDEV, V
    KASPER, P
    LAMPRECHT, I
    MUTATION RESEARCH, 1987, 192 (04): : 263 - 269
  • [30] INDUCTION OF SISTER-CHROMATID EXCHANGES BY PROCARCINOGENS IN METABOLICALLY COMPETENT CHINESE-HAMSTER EPITHELIAL LIVER-CELLS
    DESALVIA, R
    MESCHINI, R
    FIORE, M
    POLANI, S
    PALITTI, F
    CARLUCCIO, MA
    TURCHI, G
    MUTATION RESEARCH, 1988, 207 (02): : 69 - 75
12345