Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones

被引：0

作者：

G. Turchi

H.R. Glatt

A. Seidel

A. Puliti

I. Sbrana

机构：

[1] J.R.C. Environmental Institute,European Centre for the Validation of Alternative Methods (ECVAM)

[2] German Institute of Human Nutrition,Institute of Toxicology

[3] University of Mainz,undefined

[4] Dipartimento di Scienze dell‘Ambiente e del Territorio dell’Universita',undefined

来源：

Cell Biology and Toxicology | 1997年 / 13卷

关键词：

cultured liver cells; chromosomal aberrations; structure-activity relationship;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect. However, all four compounds enhanced the frequency of c-mitoses.

引用

页码：155 / 165

页数：10

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