Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

被引：0

作者：

Giuseppina Stifano

Romy Beatriz Christmann

机构：

[1] Boston University School of Medicine,

来源：

Current Rheumatology Reports | 2016年 / 18卷

关键词：

Systemic sclerosis; Scleroderma; Macrophages; Monocytes; Fibrosis; Pathogenesis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The pathogenesis of systemic sclerosis is still unknown, although immune cells, mainly macrophages/monocytes, may have an important role in initiating and/or perpetuating the disease. Macrophages and monocytes are often classified as pro-inflammatory M1 phenotype or classic activation and pro-fibrotic/anti-inflammatory M2 phenotype or alternative activation. In this review, we highlighted the most relevant research regarding the involvement of macrophages/monocytes in the pathogenesis of this complex disease.

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