Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

被引：0

作者：

Giuseppina Stifano

Romy Beatriz Christmann

机构：

[1] Boston University School of Medicine,

来源：

Current Rheumatology Reports | 2016年 / 18卷

关键词：

Systemic sclerosis; Scleroderma; Macrophages; Monocytes; Fibrosis; Pathogenesis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The pathogenesis of systemic sclerosis is still unknown, although immune cells, mainly macrophages/monocytes, may have an important role in initiating and/or perpetuating the disease. Macrophages and monocytes are often classified as pro-inflammatory M1 phenotype or classic activation and pro-fibrotic/anti-inflammatory M2 phenotype or alternative activation. In this review, we highlighted the most relevant research regarding the involvement of macrophages/monocytes in the pathogenesis of this complex disease.

引用

共 50 条

[21] Do we need more scientists?
Teitelbaum, MS
PUBLIC INTEREST, 2003, (153) : 40 - 53
[22] -We need to do more research
Svanstrom, Christina
TIDSSKRIFT FOR DEN NORSKE LAEGEFORENING, 2021, 141 (07) : 678 - 681
[23] Do we need more antidepressants?
Pinder, RM
JOURNAL OF AFFECTIVE DISORDERS, 2004, 78 : S8 - S8
[24] Do we need more scientists?
Teitelbaum, Michael S.
U.S. SCIENFIFIC AND TECHNICAL WORKFORCE: IMPRIVING DATA FOR DECISIONMAKING, 2004, : 11 - 20
[25] DO WE NEED MORE GENERALISTS
GINZBERG, E
ACADEMIC MEDICINE, 1989, 64 (09) : 495 - 497
[26] DO WE NEED MORE HOSPICES
REGNARD, CFB
BRITISH MEDICAL JOURNAL, 1993, 306 (6894): : 1754 - 1754
[27] DO WE NEED MORE DOCTORS OR NOT
PARKHOUSE, J
PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1976, 69 (11): : 815 - 821
[28] Deleterious systemic effects of OSA: how much evidence do we need?
Kohler, Malcolm
THORAX, 2015, 70 (09) : 817 - 818
[29] Chest physiotherapy for children with acute bronchiolitis: Do we need more evidence?
Combret, Yann
Prieur, Guillaume
Medrinal, Clement
Lebret, Marius
HONG KONG PHYSIOTHERAPY JOURNAL, 2022, 42 (01) : 1 - 2
[30] Assessment of diastolic function: How much more evidence do we need?
Sousa, Carla
REVISTA PORTUGUESA DE CARDIOLOGIA, 2019, 38 (11) : 805 - 807

← 1 2 3 4 5 →