Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

被引：0
|
作者：
Giuseppina Stifano
Romy Beatriz Christmann
机构：
[1] Boston University School of Medicine,
来源：
Current Rheumatology Reports | 2016年 / 18卷
关键词：
Systemic sclerosis; Scleroderma; Macrophages; Monocytes; Fibrosis; Pathogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The pathogenesis of systemic sclerosis is still unknown, although immune cells, mainly macrophages/monocytes, may have an important role in initiating and/or perpetuating the disease. Macrophages and monocytes are often classified as pro-inflammatory M1 phenotype or classic activation and pro-fibrotic/anti-inflammatory M2 phenotype or alternative activation. In this review, we highlighted the most relevant research regarding the involvement of macrophages/monocytes in the pathogenesis of this complex disease.
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