Enantioconvergent synthesis of P-stereogenic allenylphosphines

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Nature Synthesis | 2022年 / 1卷
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A strategy to synthesize allenylphosphine derivatives with both P and axial chirality is developed and allows for diverse derivatizations of chiral phosphines. The Ni-catalysed enantioconvergent reaction occurs without racemization or symmetrization of the propargylic carbonate substrate, as demonstrated by combined experimental and computational methods.
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页码:680 / 681
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